期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

垂体瘤转化基因在唾液腺腺样囊性癌侵袭转移中的作用 被引量：1

Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma
原文传递
导出
摘要 目的:研究垂体瘤转化基因(PTTG)的表达在唾液腺腺样囊性癌(SACC)侵袭和转移中的作用。方法:应用免疫组织化学SP法检测40例SACC组织及20例癌旁正常组织中PTTG和碱性成纤维细胞生长因子(bFGF)的表达。采用SPSS11.5软件包,应用χ2检验和Spearman相关性分析进行统计学处理。结果:SACC组织中PTTG和bFGF的蛋白表达显著高于癌旁正常组织(P均<0.01);PTTG与bFGF的蛋白表达水平呈正相关(P<0.01)。结论:PTTG与bFGF在SACC组织中高表达,PTTG的表达与SACC的侵袭和转移密切相关。 PURPOSE： To study the effect of pituitary tumour transforming gene （FI＇TG） on invasion and metastasis of salivary adenoid cystic carcinoma. METHODS： The expression of PT＇FG and bFGF was investigated in 40 salivary adenoid cystic carcinoma tissues and 20 normal salivary tissues by immunohistochemistry. Pearson＇s Chi-square test and Spearman correlation analysis were used to analyze the data using SPSS 11.5 software package. RESULTS： The expression of I^TG and bFGF were significantly higher in salivary adenoid cystic carcinoma tissues than in normal salivary gland tissues（P〈0.01 ）and their expression levels were positively correlated （P〈0.01）. CONCLUSIONS： PqTG and bFGF are highly expressed in salivary adenoid cystic carcinoma. The invasion and metastasis of salivary adenoid cystic carcinoma are correlated with the expression of FTFG. Supported by National Natural Science Foundation （81102058）.
作者 戚忠政 刘洁 刘法昱 孙长伏
机构地区 中国医科大学口腔医学院 辽宁省口腔医学研究所口腔颌面外科 中国医科大学中心实验室
出处 《上海口腔医学》 CAS CSCD 北大核心 2013年第6期667-670,共4页 Shanghai Journal of Stomatology
基金 国家自然科学基金青年基金(81102058)~~
关键词 垂体瘤转化基因 唾液腺腺样囊性癌 免疫组织化学 Pituitary tumor transforming gene Salivary adenoid cystic carcinoma Immunohistochemistry
分类号 R739.87 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1芦杨,齐鸿亮.MMP-2和MVD在腺样囊性癌中的表达及临床意义[J].中国实用口腔科杂志,2009,2(7):415-417. 被引量：5
  • 2Vlotides G,Eigler T,Melmed S. Pituitary tumor-transforming gene:physiology and implications for tumorigenesis[J].ENDOCRINE REVIEWS,2007,(02):165-186.doi:10.1210/er.2006-0042.
  • 3Salehi F,Kovacs K,Scheithauer BW. Pituitary tumortransforming gene in endocrine and other neoplasms:a review and update[J].Endocrine Related Cancer,2008,(03):721-743.
  • 4Yan S,Zhou C,Lou X. PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma[J].CANCER RESEARCH,2009,(08):3283-3290.doi:10.1158/0008-5472.CAN-08-0367.
  • 5Tas F,Duranyildiz D,Oguz H. Circulating serum levels of angiogenic factors and vascular endothelial growth factor receptors-1 and 2 in melanoma patients[J].MELANOMA RESEARCH,2006,(05):405-411.doi:10.1097/01.cmr.0000222598.27438.82.
  • 6Minematsu T,Suzuki M,Sanno N. PTTG overexpression is correlated with angiogenesis in human pituitary adenomas[J].ENDOCRINE PATHOLOGY,2006,(02):143-153.
  • 7Hunter JA,Skelly RH,Aylwin SJ. The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas[J].European Journal of Endocrinology,2003,(02):203-211.
  • 8Ishikawa H,Heaney AP,Yu R. Human pituitary tumortransforming gene (PTTG) induces angiogenesis[J].Journal of Clinical Endocrinology and Metabolism,2001,(02):867-874.
  • 9Okada-Ban M,Thiery JP,Jouanneau J. Fibroblast growth factor2[J].International Journal of Biochemistry and Cell Biology,2000,(03):263-267.
  • 10Torimura T,Ueno T,Kin M. Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of β1 integrins[J].HEPATOLOGY,2001,(01):62-71.

二级参考文献6

  • 1Rubatt JM,Darcy KM,Hutson A,et al.Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31,CD105,p53status,and angiogenic marker expression:a gynecologic oncology group study[].Gynecologic Oncology.2009
  • 2Saad RS,Jasnosz KM,Tung MY,et al.Endoglin (CD105) expression in endometrial carcinoma[].International Journal of Gynecological Pathology.2003
  • 3Weidner N.Intratumor Microvessel Density as a prognostic factor in cancer[].American Journal of Pathology.1995
  • 4Nagel H,Laskawi R,Wahlers A,et al.Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1, -2, and -3 in benign and malignant tumours of the salivary gland[].Histopathology.2004
  • 5Egeblad M,Werb Z.New functions for the matrix metalloproteinases in cancer progression[].Nature Reviews Cancer.2002
  • 6Fingleton,B.Matrix metalloproteinases as valid clinical targets[].Current Pharmaceutical Design.2007

共引文献4

同被引文献44

  • 1郭莹,赵颖海.肿瘤中Fas基因的研究进展[J].广东医学院学报,2014,32(1):91-93. 被引量：5
  • 2刘伦华,楼丽广.PTEN功能调节的研究进展[J].中国药理学通报,2005,21(7):778-781. 被引量：16
  • 3Taran FA, Stewart EA, Brucker S. Adenomyosis : epidemiology, risk factors,clinical phenotype and surgical and intervemiortal alterna- tives to hysterectomy [ J ]. Geburtshilfe Frauenheilkd, 2013, 73 (9) :924-931.
  • 4Stilley JA, Birt JA, Sharpe-Timms KL. Cellular and molecular basis for endometriosis-associated infertility [ J ]. Cell Tissue Res, 2012, 349(3) :849-862.
  • 5Kitawaki J, Obayashi H, Ishihara H, et al. Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata[ I ]. Hum Reprod,2001,16( 1 ) :51-55.
  • 6Bischoff F, Simpson JL. Genetic basis of endometriosis [ J ]. Ann N Y Acad Sci,2004,1034:284-299.
  • 7Davies EM,Sheffield DA,Tibarewal P,et al. The PTEN and Myo- tubularin phosphoinositide 3-phosphatases:linking lipid signalling to human disease [ J ]. Subcell Biochem,2012,58,281-336.
  • 8Sonveaux P, Copetti T, De Saedeleer CJ et al. Targeting the lactate transporter MCTI in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis [ J ]. PLoS One, 2012, 7 (3) :e33418.
  • 9Takei Y, Saga Y, Mizukami H, etal. Overexpression of PTEN in ovarian cancer cells suppresses i. p. dissemination and extends sur- vival in mice[ J]. Mal cancer Ther,2008,7 (3) :704-711.
  • 10Zheng H, Takahashi H, Murai Y, etal. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth,invasion, metastasis and angiogenesis of gastric carcinoma [ J ]. Antieanaer Res, 2006, 26(5 ) :3579-3583.

引证文献1

二级引证文献3

上海口腔医学
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部