摘要
目的:探讨强化胰岛素治疗对重症感染患者淋巴细胞亚群及降钙素原的影响。方法:选择本院收治的重症感染导致多器官功能衰竭患者53例,随机分为两组:常规治疗组26例,血糖控制目标为10.0～11.1mmol/L;胰岛素强化治疗组27例,血糖控制目标为4.4～6.1mmol/L,观察两组患者治疗前后SOFA评分、APACHEⅡ评分、淋巴细胞亚群、降钙素原水平情况。结果:强化治疗组与常规治疗组相比,SOFA评分、APACHEⅡ评分、淋巴细胞亚群、降钙素原水平差异均有统计学意义(P<0.05);强化治疗组治疗前后淋巴细胞亚群差异有统计学意义(P<0.05)。结论:对重症感染患者进行强化胰岛素治疗及监测血清降钙素原水平、淋巴细胞亚群情况对评估机体免疫功能、判断预后、降低患者死亡率都有重要意义。
Objective：To investigate influence of intensive insulin therapy on t-lymphocyte subpopulations and procalcitonin（PCT）in patients with severe infection.Method：A total of 53patients with severe infection were randomly divided into intensive insulin therapy group and conventional treatment group.Blood glucose in intensive insulin therapy group was maintained at 4.4-6.1mmol/L;conventional treatment group was maintained at 10.0-11.1mmol/L.APACHE Ⅱscores,SOFA scores,T-lymphocyte subpopulations,procalcitonin were measured.Results：The difference in APACHE Ⅱ scores,SOFA scores,T-lymphocyte subpopulations,procalcitonin between two groups were significantly different（P 0.05）.T-lymphocyte subpopulations of intensive insulin therapy group were significant different between that before and after treatment（P0.05）.Conclusion：For severe infection,intensive insulin therapy and asessing T-lymphocyte subpopulations,PCT play an impotant role in reducing the fatality rate and improving prognosis.
出处
《海南医学院学报》
CAS
2014年第1期93-95,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210935)~~
关键词
重症感染
强化胰岛素治疗
淋巴细胞亚群
降钙素原
Severe infection
Intensive insulin therapy
T-lymphocyte subpopulations
Procalcitonin（PCT）
