摘要
目的探讨MCP-1和BMP-7在耳部瘢痕疙瘩形成中的作用,为临床防治提供理论参考。方法采用免疫组化法对29例耳部瘢痕疙瘩组织、21例非病理性瘢痕组织和22例正常皮肤组织中MCP-1和BMP-7表达情况进行检测,并对耳部瘢痕疙瘩组织中MCP-1和BMP-7表达相关性进行研究。结果耳部瘢痕疙瘩组MCP-1阳性率为82.76%,明显高于非病理瘢痕组(28.57%)和对照组(9.09%),组间相比差异具有统计学意义(χ2=12.033、24.350,P<0.05);耳部瘢痕疙瘩组BMP-7阳性率为17.24%,明显低于非病理瘢痕组(57.14%)和对照组(81.82%),组间相比差异有统计学意义(χ2=9.442、18.432,P<0.05)。耳部瘢痕疙瘩组织中MCP-1与BMP-7表达呈负相关关系(r=-0.538,P<0.05)。结论 MCP-1和BMP-7共同参与调节耳部瘢痕疙瘩形成过程,BMP-7可以作为防治耳部瘢痕疙瘩一个理想的基因治疗位点。
Objective To explore the roles of MCP-1 and BMP-7 in the formation of auricular keloids. Methods Im- munohistochemistry method was used to detect MCP-1 and BMP-7 expression in 29 cases of auricular keloid tissues and 22 cases of normal skin tissue. The correlation between MCP-1 and BMP-7 expression in auricular keloid tissues was discussed. Results The positive rate of MCP-lin auricular keloids group was 82.76%, which was significantly higher than that of non-pathological scar group （28.57%） and the control group（9.09% ） （X2 = 12. 033, 24. 350; all P 〈 0.05 ） ; The positive rate of BMP-7 in keloids group was 17.24%, which was significantly lower than that of non-path- ological scar group （57.14%） and the control group（81.82% ） （X2 =9. 442, 18. 432; all P 〈0.05）. A negative correlation between MCP-1 and BMP-7 expression of auricular keloid tissues was noted （ r = - 0. 538, P 〈 0.05 ）. Conclusion MCP-1 and BMP-7 participate in the regulation of auricular keloid formation process. BMP-7 can be used as an ideal target in gene therapy to prevent keloids.
出处
《山东大学耳鼻喉眼学报》
CAS
2013年第6期35-37,41,共4页
Journal of Otolaryngology and Ophthalmology of Shandong University
