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系统性红斑狼疮外周血Th1、Th2类细胞因子与血液系统损害的关系 被引量：8

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摘要 目的探讨系统性红斑狼疮(SLE)外周血Th1、Th2类细胞因子与血液系统损害间的关系。方法选取SLE合并血液系统损害患者49例(损害组),另选26例SLE无血液系统损害患者(对照组)。采用ELISA法检测两组外周血IL-2、IL-6、IL-10、TNF-α水平。结果损害组外周血IL-6、TNF-α水平分别为(22.47±10.86)、(64.82±24.86)pg/mL,对照组分别为(17.53±8.55)、(50.14±22.95)pg/mL,P均<0.05。损害组单纯贫血者IL-10为(45.67±14.32)pg/mL,低于对照组(58.31±19.59)pg/mL,P<0.05;两系损害者IL-6及TNF-α水平分别为(24.44±10.60)、(67.72±27.88)pg/mL,均高于对照组(P均<0.05)。损害组IL-6、IL-10水平与血小板计数呈负相关(r分别为-0.365、-0.049,P均<0.05)。结论 Th2细胞因子在SLE血液系统损害的发生机制中起重要作用,特别是针对血小板损伤;Th1细胞因子在这方面处于次要地位。
作者 陈明 巩路
机构地区 天津医科大学总医院
出处 《山东医药》 CAS 2013年第48期70-71,共2页 Shandong Medical Journal
关键词 系统性红斑狼疮 血液系统损害 白细胞介素6 白细胞介素10 肿瘤坏死因子α
分类号 R593.241 [医药卫生—内科学]
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参考文献11

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二级参考文献17

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共引文献18

同被引文献123

引证文献8

二级引证文献69

山东医药
2013年 第48期

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