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染色体12p13的rs12425791位点基因多态性与急性缺血性卒中短期预后的关系 被引量：3

Study on relativity of genetic variants of rs12425791 on chromosome 12p13 and prognosis in patients with acute ischemic stroke
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摘要 目的：探讨染色体12p13的rs12425791位点基因多态性与急性缺血性卒中（AIS）短期预后（1年）的关系。方法选择401例AIS患者，运用PCR-RFLP法检测染色体12p13的rs12425791位点基因型，患者出院后随访1年，观察患者死亡和再发缺血性卒中情况。运用Logistic回归模型分析个体基因型和脑卒中预后的关系。结果401例AIS患者中，有31例发生死亡和复发卒中。在校正了年龄、性别和病史等因素后，Logistic回归分析结果显示，rs12425791纯合子突变（AA型基因）的AIS患者1年内发生死亡或再发卒中的危险度较高，是GG型基因患者的2．602倍（95％CI1．216～5．564）。结论染色体12p13的rs12425791位点纯合子突变是AIS患者短期预后不良的独立危险因素。 Objective To investigate the association between genetic variants of rs 12425791 on chromosome 12p13 and the one year risk of stroke-related death or recurrent stroke following initial stroke .Methods A total of 401 acute ischemic stroke（AIS） patients who had first-ever ischemic stroke were analyzed .The genotypes of chromosome 12p13 rs12425791 were analyzed by PCR-RFLP .Logistic regression analysis was used to assess the effect of individual genotype on stroke-related mortality or recurrent stroke in one year .Results Among the 401 AIS patients ,31 died or developed a recurrent stroke .After adjustment for age ,sex and vascular risk factors ,logistic regression analysis indicated that the odd ratio were 2 .602（95% CI 1 .216-5 .564） for individuals with homozygous variant allele of rs12425791 .Conclusion This study found that genetic variants of rs12425791 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke .
作者 曹正余
机构地区 云南省第一人民医院急诊内科
出处 《重庆医学》 CAS CSCD 北大核心 2013年第33期4004-4006,共3页 Chongqing medicine
关键词 基因型 多态性 单核苷酸 急性缺血性卒中 染色体12p13 genotype polymorphism, single nucleotide mononucleotide acute ischemic stroke chromosome 12 pl 3
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献14

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二级参考文献13

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共引文献33099

同被引文献27

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引证文献3

二级引证文献18

重庆医学
2013年 第33期

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