摘要
目的 介绍端粒、端粒酶的性质及其与肿瘤的关系 ,了解端粒、端粒酶在胃癌中的表达及意义。方法 综述国内外进展。结果 端粒酶活性在 85 %～ 90 %的胃癌中可以检测到 ,在表达端粒酶阳性的患者比表达阴性的患者预后要差 ,表明端粒酶阳性的胃癌恶性程度更高。结论 胃癌端粒酶活性检测不仅可用于诊断 ,且可用于表示预后 ,未来用于抑制端粒酶的药物可以提供一种副作用较少的治疗癌症的方法。
Objective\ To introduce telomeres, telomerase and their expression in gastric carcinoma. Methods The related literatures were collected and reviewed.Rsults\ In summary, telomerase activity could be detected in 85%-90% of gastric cancer. Moreover, the patient with telomerase positive tumors showed poorer prognosis than those with telomerase negative tumours, indicating that telomerase positive gastric cancer might have more malignant potential. Conclusion Knowledge of telomerase activity in gastric cancer may be useful in cancer diagnosis, as well as a prognostic indicator of clinical outcome. Future development of drugs aimed at telomerase inhibition may potentially provide a therapy with relatively less side effects.
出处
《中国普外基础与临床杂志》
CAS
2001年第1期56-58,共3页
Chinese Journal of Bases and Clinics In General Surgery
