摘要
目的:探讨阿片类物质依赖合并高血压病患者戒毒期间临床治疗效果。方法:对216名阿片依赖合并高血压病患者和90例无吸毒史的高血压病患者均采用CCB、ACEI、利尿剂、ARB、β-受体阻滞剂5种降压药物治疗。结果:阿片依赖合并高血压病患者在用药3个月时难治性高血压比例为79.63%,药物治疗6个月后降至55.09%(P<0.01);平均用药数量在3个月和6个月时分别为3.30±s 1.08种和2.60±s 0.95种(P<0.05),远高于同时期无吸毒史的高血压病患者水平1.90±s 0.81种和1.86±s 0.73种(P<0.01)。结论:阿片依赖合并高血压病患者用药种类和难治高血压比例均高于无吸毒史的高血压病患者,且在戒毒早期对降压药物敏感性降低。
Objective： To investigate the effect of different antihypertensive drugs on the hypertensive patients with opioid dependence. Methods ：The case group of 216 hypertensive patients and control gruop of 90 hypertensive patients without opioid dependence were treated by CCB, ACEI, diuretics,ARB, beta - receptor blockers, five kinds of antihypertensive drugs. Results：In hypertensive patients with opioid dependence, the percentage of refractory hypertension was 79.63% after the first three months of medication, and it dropped to 55.09% after six months（P 〈 0.01 ）. The average medication number at 3 months and 6 months were 3.30 -＋ s 1.08 and 2.60 ＋ s 0.95 （ P 〈 0.05 ）, were higher than the level of hypertensive patients without opioid dependence （P 〈 0.01 ）. Cortclusion：In the hypertensive patients with opioid dependence, medication number and the proportion of refractory hypertension were higher than that in hypertensive patients without opioid dependence, and the sensitivity to antihypertensive drugs decreased in the early phase of treatment.
出处
《中国药物依赖性杂志》
CAS
CSCD
2013年第6期437-440,共4页
Chinese Journal of Drug Dependence
