摘要
目的 探讨缺血性卒中后非流利性失语患者静息态功能磁共振成像（functionalmagnetic resonance imaging fMRI）的脑功能特点.方法 对17例缺血性卒中后非流利性失语患者以及19名年龄、性别和受教育程度均匹配的健康对照者进行静息态fMRI检查,采用局部区域一致性（regional homogeneity,ReHo）分析方法计算静息态下脑区的ReHo情况.结果 与对照组比较,患者组左侧额上回、右侧额下回、右侧脑岛以及右侧缘上回ReHo值增高,右侧小脑半球、左侧颞上回、颞中回以及右侧颞下回脑区ReHo值降低.结论 在静息状态下,缺血性卒中后非流利性失语患者存在多个脑区ReHo异常,这种异常改变可能与其功能损伤后修复的代偿作用有关.
Objective To investigate the brain function characteristics of resting-state functional magnetic resonance imaging （fMRI） in patients with non-fluent aphasia after ischemic stroke.Methods Seventeen patients with non-fluent aphasia after ischemic stroke and 19 age-,sex-,and education-matched normal healthy subjects were examined with resting-state fMRI.The regional homogeneity （ReHo） analysis was used to calculate the ReHo of resting state in brain regions.Results Compared to the control group,the ReHo values of left superior frontal gyrus,right inferior frontal gyrus,right insular,and supramarginal gyrus increased in the aphasia group; the ReHo values of right cerebellar hemisphere,left superior temporal gyrus,left middle temporal gyrus,and right inferior temporal gyrus decreased.Conelusions In the resting state,the patients with non-fluent aphasia have ReHo anomalies in multiple brain regions.Such abnormal changes may be associated with the compensatory role of repairing after functional damage.
出处
《国际脑血管病杂志》
北大核心
2013年第10期764-768,共5页
International Journal of Cerebrovascular Diseases
基金
广东省自然科学基金（S2011010005641）
关键词
失语
卒中
脑缺血
脑图
磁共振成像
大脑皮质
Aphasia
Stroke
Brain Ischemia
Brain Mapping
Magnetic Resonance Imaging
Cerebral Cortex
