摘要
目的:探讨卡培他滨联合奥沙利铂治疗晚期结肠癌的临床效果。方法:选择笔者所在医院晚期结肠癌患者共37例,均给予卡培他滨联合奥沙利铂,观察本组患者近期临床效果及不良反应发生情况。结果:本组患者完全缓解率5.4%,部分缓解率35.1%,稳定率35.1%,进展率24.3%;有效率40.5%,临床获益率75.7%。本组患者治疗过程中,严重不良反应主要为神经毒性和手足综合征,其发生率分别为54.1%和29.7%。结论:卡培他滨联合奥沙利铂治疗晚期结肠癌近期疗效显著,不良反应轻,患者可耐受,值得临床推广应用。
Objective： To explore the clinical effect of capecitabine combined with oxaliplatin in the treatment of advanced eolorectal cancer.Method： Thirty- seven cases with advanced colon cancer were selected.All patients were given capecitabine combined with oxaliplatin.Clinical effect and adverse reaction incidence of all patients were observed.Result： The rate of complete remission in the group was 5.4%, the rate of partial remission was 35.1%, the rate of stabilization was 35.1%, the rate of progressian was 24.3%.The effective rate was 40.5%.The clinical benefit rate was 75.7%.Hand-foot syndrome and neurotoxicity were the serious adverse reactions, the incidence rates were 54.1% and 29.7% respectively.Conclusion： Capecitabine combined with oxaliplatin in the treatment of advanced colorectal cancer has significantly clinical efficacy, and have lower adverse reaction incidence, have tolerance to adverse reactions by patients.It is worthy of clinical popularization and application.
出处
《中外医学研究》
2013年第33期10-11,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
结肠癌
晚期
卡培他滨
奥沙利铂
Colon cancer
Advanced
Capecitabine
Oxaliplatiu
