摘要
目的 探讨骨桥蛋白 (OPN)与肾结石的关系。 方法 对 2 2例结石病人和 12例正常人尿骨桥蛋白及晶体成分的浓度进行检测。 结果 正常组、结石组手术前后尿骨桥蛋白的相对浓度分别为 2 9.30、2 6 .17和 10 .84。正常组尿镁和柠檬酸浓度分别为 3.86mmol/L和 1.42mmol/L ,结石组分别为 1.14mmol/L和 0 .33mmol/L ,组间差别有显著性意义 (P <0 .0 5 )。 结论 尿骨桥蛋白等抑制物分泌减少是尿石症发病的主要因素之一。
Objective To investigate the relationship between osteopontin and urolithiasis. Methods Concentrations of urinary osteopontin and crystal components were determined. Results Relative concentrations of urinary osteopontin in normal, pre and postoperative stone former group were 29.30 ,26.17 and 10.84 respectively. Concentrations of urinary magnesium and citrate were 3.86 mmol/L and 1.42 mmol/L respectively in normal control, while these were 1.14 mmol/L and 0.33 mmol/L respectively in stone formers, and there were significant differences between the two groups ( P <0.05). Conclusions Deficiency of urinary inhibitors such as osteopontin was one of the main factors in the pathogenesis of urolithiasis.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2000年第12期709-711,共3页
Chinese Journal of Urology
基金
国家自然科学基金资助!(396 70 72 2 )
