摘要
目的评价孟鲁司特钠治疗轻度儿童睡眠呼吸障碍(SBD)的临床疗效,为轻度儿童SBD的治疗提供合理的用药方案和临床依据。方法采用计算机和手工检索方式检索2000—2012年PubMed、OVID、Science online、BMJ、Springer Link、MEDLINE、中国全文期刊数据库、万方数据库发表或未发表的文献。文献资料由2名评价者用统一的表格独立提取,对文献质量进行内部真实性评价,并按Cochrane协作网推荐的方法进行评价和分析。结果共有2篇文献符合纳入标准,均为高质量的随机对照试验(RCT),其中孟鲁司特钠组共46例,对照组共30例。Meta分析结果显示:在呼吸暂停低通气指数(AHI)、觉醒指数、呼吸暂停指数、平均睡眠潜伏期变化方面,孟鲁司特钠组均优于对照组(P<0.05);在平均血氧饱和度、睡眠效率变化方面,孟鲁司特钠组与对照组间差异无统计学意义(P>0.05)。结论孟鲁司特钠可有效治疗轻度儿童SBD,但由于符合纳入标准的RCT过少,其长期疗效及安全性等仍需进一步研究。
Objective To assess the clinical curative effect of montelukast sodium （MS） on child light sleep - disor- dered breathing （ SBD）, to provide reasonable drug regimens and a clinieal basis. Methods The published or unpublished lit- eratures from the year 2000 to 2012 were retrieved in PubMed, OVID, Science online, BMJ, Springer Link, MEDLINE, CJFD, Wanfang Data and other databases. The literatures were extracted independently by 2 valuators using unified forms. Their quality was given an internal validity assessment and analyzed using the methods recommended by Cochrane network. Results Two high- quality literatures on randomized controlled trials （RCT） were enrolled in this study, including 46 patients in MS group, 30 in control group. By Meta analysis, MS group was superior to control group in average changes of apneahypopnea in- dex （ AHI）, arousal index, apnea index （ AI）, mean sleep latency （P 〈 O. 05 ）. There was no significant difference in mean oxygen saturation, mean sleep efficiency changes between 2 groups （ P 〉 0.05 ）. Conclusion MS can treat child Light SBD ef- fectively, but its long - term curative effect and safety remains to be researched further due to too few RCTs in line with the inclu- sion criteria.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第32期3828-3832,共5页
Chinese General Practice
关键词
META分析
睡眠呼吸障碍
儿童
治疗结果
孟鲁司特钠
Meta - analysis
Sleep - disordered breathing
Child
Treatment outcome
Montelukast sodium
