摘要
目的探讨血清ＴＧＦβ１和糖尿病肾病的关系。方法４５例２型糖尿病根据原白蛋白排泄率（ＵＡＥＲ）分为正常蛋白尿组（ＮＡ）、微量蛋白尿组（ＭＡ）、临床蛋白尿组（ＯＤＮ）。分别检测各组的血清ＴＧＦβ１、空腹血糖（ＦＢＧ）、糖化血红蛋白（ＨｂＡｌｃ）及肾功能（ＢＵＮ、Ｃｒ、Ｃｃｒ）。ＭＡ、ＯＤＮ分别分为卡托普利治疗组、常规治疗组。结果糖尿病三组与正常对照组比较血清ＴＧＦβ１有显著性差异，ＯＤＮ与ＭＡ、ＮＡ比较也有显著性差异。相关分析表明血清ＴＧＦβ１与血Ｃｒ、ＨｂＡｌｃ、ＵＡＥＲ呈正相关。ＭＡ和ＯＤＮ两组中卡托普利治疗前后ＴＧＦ民有显著性差异。结论糖尿病肾病患者血清ＴＧＦ昆明显增高，且和糖化血红蛋白、肾功能损害呈明显正相关。血管紧张素转换酶抑制剂能部分地纠正 ＤＮ ｔ者的血清ＴＧＦβ１变化。
Objective To explore the relation between serum TGFβ1 and diabetic nephropathy(DN). Methods Forty-five cases of type 2 diabetes mellitus patients were divided into three groups according to urine albumium excretion rate (UAER): normoalbuminuria (NA)group; microalbuminuria (MA) group; macroalbuminuria group (overt DN). Serum TGFβ1, fasting blood glucose (FBG), HbAlc.BUN. Cr. Ccr were detected in all cases. Microalbundnuria group and macroalbuminuria group were respectively divided into group.treated with captopril and regular treatment group. Results Serum TGFβ1, had significantly differences in four groups(23. 95±8. 01ng/ml vs 35.02±6. 70ng/ml, 39.3i± 5. 35ng/ml vs 58. 58±9. 56ng/ml,P<0. 01 ). Serum TGFβ1, was in positive correlation with Cr (r=0. 390,P<0.05), HbAlc (r=0. 676, P<0. 01), and UARE (r= 0. 777, P<0. 04). Serum TGFβ1, had significantly differences after treatment with captopril in MA group and ODN group. Conclusion diabetic nephropathy patients have a higher serum TGFβ1, compare with controls and incipient DN. Serum TGFβ1, was in positive correlation with HbAlc and lesion of renal function. ACEI can partly ameliorate the change of serum TGFβ1 in DN.
出处
《中国糖尿病杂志》
CAS
CSCD
2000年第6期336-338,共3页
Chinese Journal of Diabetes
关键词
2型糖尿病
糖尿病肾病
转化生长因子β_(1)
Type2 diabetes mellitus
diabetic nephropathy
Transforming growth factor-β_(1)
