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烧伤患者创面1246株病原菌分布特点及耐药情况分析 被引量:8

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摘要 目的了解近年烧伤患者创面病原菌分布特点及耐药情况。方法选择2006年1月一2011年12月笔者单位烧伤科559例患者1422份创面分泌物标本,共分离出病原菌1246株。应用全自动微生物鉴定药敏仪及配套试剂进行菌种鉴定和药物敏感试验。采用EpiCenter微生物管理软件,统计分析各年度烧伤创面病原菌分布情况及主要革兰阴性杆菌、革兰阳性球菌对抗生素的敏感率变化情况。结果1246株病原菌中,革兰阴性杆菌696株占55.86%,革兰阳性球菌530株占42.54%。金黄色葡萄球菌检出率最高,共249株占19.98%,其次为铜绿假单胞菌152株占12.20%。6年间,金黄色葡萄球菌检出率较稳定,铜绿假单胞菌检出率呈上升趋势。检出的金黄色葡萄球菌和表皮葡萄球菌中,甲氧西林耐药金黄色葡萄球菌和甲氧西林耐药表皮葡萄球菌分别占63.45%(158/249)和75.00%(54/72)。未检出万古霉素、利奈唑胺耐药金黄色葡萄球菌和表皮葡萄球菌。检出的粪肠球菌和屎肠球菌中,万古霉素耐药率分别为5.19%和12.90%。检出的铜绿假单胞菌对阿米卡星、美罗培南及哌拉西林/他唑巴坦敏感率大于60.00%。检出的鲍氏不动杆菌、鲍氏醋酸钙复合不动杆菌对10种常见抗生素的敏感率为2.50%~40.00%。检出的肠杆菌科细菌,主要包括大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌,3种细菌对亚胺培南、美罗培南敏感率均为100.00%。产超广谱B内酰胺酶(ESBL)大肠埃希菌检出率为59.78%(55/92),对阿米卡星与哌拉西林/他唑巴坦敏感率大于80.00%;产ESBL肺炎克雷伯菌的检出率为50.00%(27/54),对左氧氟沙星与阿米卡星敏感率大于60.00%;阴沟肠杆菌对阿米卡星敏感率大于80.00%。结论笔者单位烧伤科2006—2011年烧伤创面病原菌中,居前5位的依次为金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、鲍氏醋酸钙复合不动杆菌、鲍氏不动杆菌,其中后2种细菌对所有抗生素的敏感率极低。
出处 《中华烧伤杂志》 CAS CSCD 北大核心 2013年第6期558-560,共3页 Chinese Journal of Burns
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共引文献182

同被引文献48

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