摘要
目的 了解 β-内酰胺类抗生素与酶抑制剂的联合药物新型剂 -阿莫西林 /克拉维酸分散片 (AMC)的体外抗菌活性。方法 采用稀释法将该药对临床 2 34株产 β-内酰胺酶菌进行体外抗菌活性的测定 ,并与原片剂作比较 ;同时对 AMC分散片在不同的 p H值、细菌接种量及血清浓度等条件影响下的最小抑菌浓度 (MIC)分别做了检测。结果 AMC分散片与原片剂具有相似的抗菌谱和抗菌活性 ,但杀菌曲线实验显示 :分散片能在 2 4h内有效地杀灭金葡菌和大肠埃希菌 ,而原片剂则在 2 4h后细菌活菌数有恢复的现象 ;p H偏酸或偏碱及细菌接种量的增加对该药的杀菌效果均有一定的减弱作用。结论 AMC制成分散片后 ,使其服用方便、吸收快。
OBJECTIVE To observe the in vitro antibacterial activities of Amo/Cla (amoxicillin/clavulanic acid) dispersible tablets. METHODS The drugs against 234 strains of β lactamase producing bacteria were studied by the diluting methods. The difference on quantum of bacteria, serum concentration, pH of culture medium etc were detected also. RESULTS The antibacterial activity of Amo/Cla dispersible tablets was the same as ordinary tablets. KC 3 Test indicated that bacterium was killed with Amo/Cla dispersible tablets in 24 hours. But in ordinary tablets, bacteria can grow again. The action of Amo/Cla dispersible tablets was repressed when pH<6.0 or pH>8.0, and when serum concentration >50%, this result was clear in S.aureus. In same condition, the dissolved speed of dispersible tablets was faster than that of ordinary tablets. CONCLUSIONS After dispersible tablets were produced, the antibacterial activity was not changed.
出处
《中华医院感染学杂志》
CAS
CSCD
2000年第6期415-417,共3页
Chinese Journal of Nosocomiology
关键词
阿莫西林
克拉维酸
分散片
体外抗菌活性
Amoxicillin/clavulanic acid
Dispersible tablets
β Lactamases
in vitro Antibacterial activitt
