摘要
目的 探讨庚型肝炎病毒 (HGV)的致病性。方法 应用RT nPCR检测 36 8例肝炎患者血清HGVRNA和血清酶的变化 ,并对其中 1例单独庚型肝炎肝硬化病例进行肝脏活组织病理检测。结果 在 71例急性黄疸型肝炎中检出单纯性HGVRNA阳性 7例 ,15 5例慢性肝炎中检出单纯性HGVRNA阳性 2 2例 ,5 1例肝硬化中检出单纯HGVRNA阳性 3例。其中 1例肝穿组织免疫组化证实为HGVNS 5Ag阳性。结论 急性黄疸型肝炎及乙、丙型肝炎病毒携带者 ,其慢性肝炎、肝硬化和肝癌中均可检出HGVRNA ,HGV感染可为单独感染或与乙 丙型肝炎病毒混合或重叠感染 ,肝脏病理和免疫组化检查证实庚型肝炎病毒是一种嗜肝病毒 ,其定位主要存在于细胞浆内 ,可引起慢性病毒性肝炎甚至肝硬化。
Objective To study the clinical,enzymatic and liver pathological changes in patients with hepatitis G virus (HGV) infection. Methods RT nested PCR was applied to detect HGV RNA in 368 patients with hepatic diseases. The liver biopsy tissue from one liver cirrhosis patient with simple HGV infection was examined. Results Simple HGV RNA positive were found in 7 cases of 71 acute hepatitis jaundice, in 22 cases of 155 chronic hepatitis and in 3 cases of 51 liver cirrhosis. The immunohistochemistry of the liver biopsy tissue from a liver cirrhosis patient showed HGV NS 5 antigen positive. However, HGV infection might occur simply or combinatively with hepatitis B or C virus or super infected. Conclusion HGV RNA could be detected in acute hepatitis jaundice,chronic hepatitis, hepatitis B or C carriers, liver cirrhosis and hepatocellular carcinoma. HGV is proved to be a hepatotropic virus by pathological examination and immunohistochemistry, the virus located in the cytoplasm of the liver cells. It may cause chronic hepatitis and even liver cirrhosis, so HGV in pathogenic to liver tissue.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2000年第4期358-360,共3页
Chinese Journal of Experimental and Clinical Virology
基金
国家863(102-07-02-0)
九五攻关课题!(96-906A-0308)
关键词
肝脏病理学
致病力
酶血清学
肝炎
庚型
Hepatitis/Pathology
Pathogenicity
Enzyme/Serology
Hepatitis G virus
