摘要
目的 观察硫普罗宁对慢性乙型肝炎氧自由基的清除作用。方法 用黄嘌呤氧化酶法对 80例慢性乙型肝炎体内的超氧化物歧化酶 (SOD)进行检测 ,并检测了丙氨酸转氨酶 (ALT)、血清总胆红素 (TBiL)、血清总蛋白 (TP)、A G比值。 40例接受常规护肝 ,退黄治疗为对照组 ;40例除接受护肝、退黄治疗外 ,口服硫普罗宁为治疗组。结果 16例正常人SOD活性检测正常值为 16 5 .9±2 3 .36NU ml。 40例治疗组与 40例对照组治疗前年龄、性别无差异 ,SOD、ALT、TBil、TP、ALB亦无差异 ,SOD分别为 10 6 .5 7± 40 .6 8与 10 5 .18± 44 .5 9。两组治疗后 ,SOD、ALT、TBil、ALB的测定值差异有显著性 (P <0 .0 1) ,SOD分别为 187.93± 35 .2 4与 15 7.96± 47.2 9;ALT分别为 38.41± 2 2 .2 2与6 8.5 2± 34.19;TBil分别为 2 3 .15± 12 .46与 30 .38± 2 1.80 ;ALB分别为 43.2 8± 4.2 1与 40 .36± 5 .19。结论 硫普罗宁对治疗慢性乙型肝炎、清除氧自由基有较好疗效 。
Objective To observe the clearance effect of Tiopronin on oxygen free radicals in chronic hepatitis B patients.Methods The ranthine oxidase assay was used to detect superoxide dismutase (SOD) in 80 chronic hepatitis B patients, the ALT,TBil,TP and A/G ratio of the patients were also tested. The 80 chronic hepatitis B patients were divided into two groups, the control group was treated with routine liver protective and jaundice regressing drugs while the treated group was additionally administered with Tiopromin bsrsides the routine treatment. Results In two groups of patients with similar ages and sexes,there showed no differences in levels of SOD, ALT,TBil,TP and ALB before treatment,as the SOD in lreated group and control group wrre 106.57 ± 40.68 NU/ml and 105.18 ± 44.59 NU/ml respectively, while the normal value for SOD in 16 normal persons was 165.9 ± 23.36 NU/ml. After treatment,there were significant differences ( P < 0.01 ) in SOD,ALT,TBil and ALB levels which showed SOD 187.93 ± 35.24 NU/ml, ALT 38.41 ± 22.22 U/L,TBil 23.15 ± 12.46 μmol/L, ALB 43.28 ± 4.21 g/L in the treated group and SOD 157.96 ± 47.29 NU/ml, ALT 68.52 ± 34.19 U/L,TBil 30.38 ± 21.80 μmol/L and ALB 40.36 ± 5.19 g/L in the control group.Conclusion There showed a good therapeutic effect of Tiopronin on the clearance of oxygen free radicals in chronic hepatitis B patients and also it can improve the liver function.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2000年第4期355-357,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
慢性活动性肝炎
SOD
巯基丙酰甘氨酶
治疗
Hepatitis,chronic active
Superoxide dismutase
Mercaptorropionylglgine/therapy
