摘要
目的探讨地佐辛复合罗哌卡因用于腹部手术后硬膜外自控镇痛(PCEA)的效果。方法腹部手术患者120例随机均分为三组:DR组采用地佐辛复合罗哌卡因,TR组采用曲马多复合罗哌卡因,MR组采用吗啡复合罗哌卡因。镇痛药剂量:地佐辛5mg,曲马多500mg,吗啡5mg,1.192%罗哌卡因20ml,均用生理盐水加至100ml;镇痛方法:负荷量5ml,维持量2ml/h,自控镇痛剂量0.5ml,锁定时间15min。记录术后4、8、12和24h的VAS疼痛评分和不良反应。结果三组术后镇痛满意,效果相当(P>0.05)。但DR组术后恶心、呕吐和皮肤瘙痒等不良反应发生率低于MR组和TR组(P<0.05)。结论地佐辛复合罗哌卡因PCEA术后镇痛效果与吗啡相当,但相关不良反应较少。
[Abstraetl Objective To observe the efficacy of patient-controlled epidural analgesia（PCEA） with dezocine-ropivacaine in the patients underwent abdominal surgery. Methods A total of 120 patients underwent abdominal surgery was equally assigned into three groups of DR （PCEA with dezocine 5 mg plus 1. 192% ropivacaine 20 ml）, TR（PCEA with tramadol 500 mg plus 1. 192% ropivacaine 20 ml） and MR（PCEA with morphine 5 mg plus 1. 192% ropivacaine 20 ml）. The drugs were diluted to 100 ml with normal saline. After a loading dose of 5 ml was injected, PCEA was conducted with basic infusion of 2 ml per hour. PCA dose was 0.5 ml in a locking time of 15 min. The VAS pain score and adverse responses were recorded at 4,8,12 and 24 hours during analgesia. Results The postoperative analgesic efficacy of three groups was satisfactory and similar with VAS pain score 〈4 points（P〉0. 05）. But the incidence rates of nausea, vomiting and skin itch were much less in group DR than those in groups of TR and MR （P〈0. 05 ）. Conclusion PCEA with dezocineropivacaine has a similar analgesic effect as that with morphine-ropivacaine but with much lower incidence of nausea,vomiting and skin itch. [Key words] Patient-controlled epidural analgesia; Dezocine
出处
《江苏医药》
CAS
北大核心
2013年第23期2852-2853,共2页
Jiangsu Medical Journal
关键词
硬膜外自控镇痛
地佐辛’
Patient-controlled epidural analgesia
Dezocine
