摘要
目的观察树突状细胞(DC)联合细胞因子诱导的杀伤细胞(CIK)免疫治疗对肾癌患者术后免疫功能影响。方法 40例肾癌患者,均采取根治性手术,术后予以DC联合CIK细胞免疫治疗。分别于治疗前1周和治疗后1周,采用流式细胞术检测免疫功能指标。结果与治疗前1周比较,治疗后1周外周血CD3+、CD4+T细胞、CD4+/CD8+比值、IL-2和INF-γ水平均明显升高,而IL-10水平明显下降(P<0.05)。结论 DC联合CIK细胞免疫治疗能显著提高肾癌患者术后的免疫功能。
Objective To observe the effect of immunotherapy with combined use of dendritic cells（IX;） and cytokine-induced killer（CIK）cells on immune function in patients after radical surgery for renal cancer. Methods The radical surgery was performed in 40 patients with renal cancer, who underwent immunotherapy with combined use of IX; and CIK cells after operation and the indicators of immune function were examined one week before and one week after treatment. Results Compared to before,the expressions of CD3＋ , CD4＋ , CD4＋/CD8＋ ratio, IL-2, interferon-γ（INF-γ） were higher, but IL-10 expression was lower, in one week after operation（P〈0. 05）. Conclusion Immunotherapy with combined use of DC; and CIK cells after operation can enhance the immune function of patients with renal cancer after operation.
出处
《江苏医药》
CAS
北大核心
2013年第23期2847-2849,共3页
Jiangsu Medical Journal
