摘要
目的 探讨脂蛋白相关磷脂酶A2（Lp-PLA2）活性水平的性别差异及其与心血管病危险因素的关系.方法 以参加“中国多省市心血管病危险因素队列研究”2002年危险因素调查的1541例北京地区45 ～ 74岁队列人群中资料完整的1471人（男性688人,女性783人）作为研究对象.Lp-PLA2活性水平采用比色法进行检测.对男女两性的Lp-PLA2活性水平以及Lp-PLA2活性与危险因素的关系进行了分析.结果 （1）男女两性Lp-PLA2活性水平分别为（22.73±8.52） nmol·min-1 ·ml-1和（20.01±8.06） nmol·min-1·ml-（P＜0.01）.（2）男性的年龄、腰围、收缩压、舒张压以及高血压患病率高于女性,女性的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）高于男性（P＜0.05或P＜0.01）.（3）Pearson相关分析显示,男性Lp-PLA2活性水平与肥胖指标（腰围和体质指数）、血压（收缩压和舒张压）、血脂（TC、LDL-C、HDL-C和甘油三酯）均相关（P均＜0.01）;女性Lp-PLA2活性水平与年龄和血脂相关（P＜0.05或P＜0.01）,而与肥胖指标和血压的相关性低于男性（女性r值0.02～0.08;男性r值0.10～0.16）.多因素logistic回归分析调整年龄、腰围、收缩压、空腹血糖、LDL-C、HDL-C、甘油三酯和高敏C反应蛋白后,男性Lp-PLA2活性水平仍高于女性（OR=1.72,95％CI：1.34 ～2.21,P＜0.01）.结论 男性的Lp-PLA2活性水平高于女性,且与主要心血管病危险因素的关系较强,但此性别差异并不能够完全由主要危险因素解释.
Objective To explore the impact of gender on lipoprotein-associated phospholipase A2 （Lp-PLA2 ） activity and association with known cardiovascular risk factors. Methods Participants in this study were recruited from Beijing sub-cohort from the Chinese Multi-provincial Cohort Study （CMCS） database. A total of 1471 participants with eomplete laboratory data were included in the study （688 male）. Lp-PLA2 activity was determined by colorimetric assay kit. Lp-PLA2 activity level and correlation between Lp-PLA2 activity and known risk factors were compared between men and women. Results （ 1 ） Lp-PLA2 activity was higher in males than in females [ （22. 73± 8. 52） nmol · min-1· m1-1 vs. （20. 01± 8.06） nmol ~ rain-l · ml-1, P 〈 0.01 ]. （2） Age, waist circumference, systolic blood pressure, diastolic blood pressure and the prevalence of hypertension were higher in males than in females, while total cholesterol, low-density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （HDL-C） were higher in females than in males（ P 〈 0. 05 or P 〈 0. 01 ）. （3）Pearson correlation showed that Lp-PLA2 activity was correlated with lipids （ total cholesterol, LDL-C, HDL-C, and triglyceride）, blood pressure （ systolic blood pressure and diastolic blood pressure）, and adiposity associated parameters （waist circumference and body mass index） in males（ all P 〈 0. 01 ） and was correlated with lipid level （total cholesterol, LDL-C, HDL-C, and triglyeeride） and age in females （ P 〈 0. 05 or P 〈 0. 01 ）. Correlations with variables associated with obesity or blood pressure in females were much weaker than those in males （ in females, r = 0. 02 - 0.08 ; in males, r = 0. 10 - 0. 16 ） . （4） After adjustment for age, waist circumference, systolic blood pressure,glucose, LDL-C, HDL-C, triglyceride and high sensitivity C-reactive protein by multiple logistic regression model, Lp-PLA2 activity was still significantly higher in males than in females （ OR = 1.72, 95% confidence interval = 1.34 - 2. 21, P 〈 0. 01 ） . Conclusions Lp-PLA2 activity and association with known cardiovascular risk factors differed in males and females. The gender difference in Lp-PLA2 activity still presents after adjustment for known cardiovascular risk factors in this cohort.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2013年第11期962-967,共6页
Chinese Journal of Cardiology
基金
国家自然科学基金（81070226）
关键词
心血管疾病
危险因素
性别因素
脂酶A
Cardiovascular diseases
Risk factors
Sex factors
Phospholipases A
