摘要
视网膜神经节细胞(retinal ganglion cells,RGCs)凋亡是青光眼、糖尿病视网膜病变、视神经炎等多种疾病过程中的一个重要环节。在这些疾病过程中,氧化应激参与诱导RGCs的凋亡。近年的实验研究发现抗氧化应激药物对RGCs有良好的保护作用。我们将近年来氧化应激诱导RGCs凋亡以及相关抗氧化应激药物的研究进展做一综述。
Apoptosis of retinal ganglion cells （ RGCs ） is an important step in the mechanism of a variety of diseases such as glaucoma, diabetic retinopathy, optic neuritis etc. In these diseases, oxidative stress induces the aopoptosis of RGCs.In recent years, many experimental studies have found that anti-oxidative stress drugs have a powerful protective efficacy in RGCs. This article reviewed the recent advances in the researches on oxidative stress-induced apoptosis of RGCs and related anti-oxidative stress drugs.
出处
《国际眼科杂志》
CAS
2013年第12期2424-2426,共3页
International Eye Science
基金
山东省中医药科技发展计划资助项目(No.2011-130)~~
关键词
视网膜神经节细胞
凋亡
氧化应激
retinal ganglion cells
apoptosis
oxidative stress
