摘要
目的研究振荡电位（ＯＰｓ）在糖尿病视网膜病变（ＤＲ）不同阶段的表现，探讨ＤＲ早期诊断的敏感性指标、并为ＤＲ国内分期提供功能学信息。方法选择８３名糖尿病患者、１５５眼，进行眼底检查、眼底摄像；按国内ＤＲ分期将患眼分成眼底无改变、１期、２期、３期、４期但无玻璃体出血等５组，对所有患眼按国际标准化方法进行ＯＰｓ检测。选择４３只正常眼作对照。结果ＯＰｓ总和振幅、ＯＰ２振幅在眼底无改变时下降．在１期时进一步下降；ＯＰ３振幅在１期时较对照下降，ＯＰ１振幅在２ 期时较对照和无改变组下降，ＯＰ４在３ 期时较对照下降４期的ＯＰ２振幅以及３期和４期的ＯＰｓ总振幅分别与０期、１期和对照组的相应指标有差异。结论ＯＰｓ和ＯＰ２振幅在ＤＲ临床前期下降，是ＤＲ早期诊断的敏感与客观性指标；ＯＰｓ及其子波振幅在ＤＲ早期和病变分期呈负相关，在ＤＲ后期的阶段性改变不明显。
Objective To investigate the manifestation of oscillatory potentials(OPs)in diabetic retinopathy (DR) with different stages,so as to provide functional and morphological information for current DR classification. Methods 83 diabetic patients, 155 eyes are selected and examed using fundus ophthalmoscpoe,fundus camera. The eyes are divided into 5 groups, stage with no visible changes (stage0) and stage 1, 2. 3, 4 according to the DR classification of the third National Ophthalmic Conference. The OPs are tested under International Society for Clinical Electrophysiology of Vision(ISCEV) protocol. Results The summed amplitude of Ops and amplitude of Op2 reduce when no fundus abnormalities can be seen and reduce further when fundus abnormalities can be seen. Compared with control, The amplitude of OP3. OP1, OP4 reduce in stage 1, 2, 3 respectively. The summed amplitude of OPs in stage 3 and 4,and also the amplitude of OP2 reduce compared with stage1, 0 and control. Conclusions The summed amplitude of OPs and the amplitude of Op2 reduce in pre-clinical stage. OPs and its wavelets correlated well with changes in early DR and in late DR, not much difference between stages could be found.
出处
《临床眼科杂志》
2000年第6期415-417,共3页
Journal of Clinical Ophthalmology
关键词
糖尿病视网膜病变
振荡电位
视网膜电流图
Diabetic Retinopathy(DR) Electroretinogram(ERG) Oscillatory Potentials(OPs)
