摘要
目的 :探讨脑出血患者急性期血浆或血清 7种神经肽含量变化及其临床意义。方法 :用放免方法检测5 4例脑出血患者血浆或血清中心钠素 (ANP)、血管紧张素 (A )、胃泌素 (Gt)、胰高血糖素 (Gc)、神经降压素 (NT)、神经肽 Y(NPY)及精氨酸加压素 (AVP)含量 ,并对部分患者进行连续观察。结果 :Gc、A 、AVP含量增高 ,NT、NPY降低 ,Gt、ANP未见改变。按出血量、出血部位分组比较 7种神经肽含量未见显著性差异。结论 :神经肽含量改变与脑出血量、出血部位之间关系不明显 ;观察 Gc。
Objective:To investigate the clinical significance of changes in neuropeptides in patients with cerebral hemorrhage during acute stage.Methods:Plasma or serum neuropeptides including artrial natriuretic peptide (ANP),angiotensin Ⅱ (A Ⅱ),gastrin (Gt),glucagon (Gc),neurotensin (NT),neuropeptide Y(NPY) and arginine vasopressin (AVP) levels were measured in 54 patients with cerebral hemorrhage by radioimmunoassay,and serial measurements were made in a part of patients.Results:Plasma Gc,AⅡ and AVP levels increased,while NT and NPY levels decreased,and no marked changes in Gt and ANP were found in these patients.No significant differences in contents of the seven peptides were found between two groups as categorized by bleeding volume and location.Conclusions:These data indicate that changes in the seven peptide contents seem to be not significantly related with both amount and location of cerebral bleeding.It will be helpful to determine Gc and AVP levels for monitoring the disease course.
出处
《中国危重病急救医学》
CAS
CSCD
2000年第12期717-719,共3页
Chinese Critical Care Medicine
基金
黑龙江省科技计划基金资助项目!(No.G96 C193)
