摘要
目的采用循证医学方法对国内胃癌术后早期肠内营养支持文献进行系统评价，为临床营养干预提供循证依据。方法计算机检索中国生物医学文献数据库、中国学术期刊、万方数据库以及维普信息资源系统中2000年1月至2013年3月的文献，按照纳入和排除标准收集国内发表的胃癌术后早期肠内营养和肠外营养比较的临床随机对照实验类文献，采用Coehrane系统评价员手册以独立、双盲的原则对纳入文献进行方法学质量评价，最后数据应用RevMan5．2软件进行Meta分析。结果纳入的14篇研究中，Meta分析表明：胃癌术后早期肠内营养与肠外营养相比，术后血清白蛋白的加权均数差为1．55，95％C1（0．81，2．29）；患者术后血清转铁蛋白的加权均数差为0．34，95％CI（0．30，0．38）；术后肛门排气时间的加权均数差为-20．66，95％CI（-23．91，-17．40）。结论胃癌患者术后早期肠内营养支持效果优于肠外营养，可以提供患者术后恢复足够的血清蛋白原，并能较早恢复胃肠道消化吸收功能，值得临床推广。
Objective In order to evaluate the nutritional effect of early enteral nutrition in patients of Chinese domestic gastric cancer surgery, using evidence-based medicine methods, and supply evidence for clinical nutrition intervention. Methods CBM, Chinese academic Journals, Wanfang database and VIP Information Resource System were searched from January 2000 to March 2013 to collect the published clini- cal randomized controlled trials literatures of nutrition support in patients of Chinese domestic gastric cancer surgery according to inclusion and exclusion criteria of literature, using the Coehrane System E- valuation Handbook independent, double-blind principle of the literature methodology quality evalua- tion. Finally Meta analysis was conducted by using RevMan5.2 software. Results 14 articles were en- rolled in the study, Meta analysis results showed that： early enteral nutrition comparing with parenteral nutrition in postoperative gastric cancer patients： the WMD of serum albumin was 1.55,95% CI （0.81,2.29）; the WMD of serum transferrin was 0.34,95%C1 （0.30,0.38）;the WMD of postoperative anal ex- haust time was -20.66,95%CI （-23.91,-17.40）. Conclusions Early enteral nutrition is better than the par- enteral nutrition, which can restore adequate serum protein source for patients, and can recover the gastrointesti- nal digestion and absorption function of itself earlier, which is worthy of clinical promotion.
出处
《中国实用护理杂志》
北大核心
2013年第35期1-6,共6页
Chinese Journal of Practical Nursing
基金
国家自然科学基金资助项目（81101750）
安徽高校自然科学研究项目（KJ20122195）
关键词
胃癌
肠内营养
早期
META分析
Gastric cancer
Enteral nutrition
Early period
Meta-analysis
