摘要
药对组成是以中医理论为原则,以中药性能功效与治法理论为基础形成的特定配伍组合,这些配伍组合或可以增进药物疗效,或降低另一药物的毒性等等。该文主要从整体动物、组织器官与细胞分子等不同水平总结药对的配伍效应,以单体成分-成分(群)配伍-单味药-药对-方剂为主线,比较评价其协同增效或配伍减毒作用,探索相关作用机制,从而为药对的临床应用和中药新药创制提供科学依据。
Chinese medicine pairs （CMP） are specific compatibility with traditional Chinese medicine （TCM） theory as principle, which was formed on basis of effect and treatment theory of TCM. The compatibility of CMP can enhance the effect, or reduce the toxicity. So, compatibility effects of CMP were studied from different pharmacology levels including animals, tissues and organs, cell and molecular levels, their synergy and compatibility attenuation were also evaluated with monomer component-component （group） compatibility-single herb-CMP-formulae as the main line, and the action mechanisms were investigated, all of which can provide scientific basis for the clinical applications of CMP and creation of TCM new drugs.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第24期4203-4207,共5页
China Journal of Chinese Materia Medica
基金
国家科技支撑计划项目(2008BAI51B01)
国家自然科学基金项目(81274058)
江苏省高校自然科学重大基础研究项目(10KJA360039)
关键词
药对
配伍效应
作用机制
整合效应
协同增效
配伍减毒
Chinese medicine pair
compatibility effect
action mechanism
integrated effect
synergy
attenuation
