摘要
为探讨补肾活血方药治疗脊髓型颈椎病的疗效及其与血清内皮素 (ET)之间的关系 ,将 44只新西兰大白兔 ,经C4～ 5椎间隙拧入螺钉造成兔颈髓腹侧慢性渐进性压迫而形成脊髓型颈椎病模型。造模成功后 ,随机分为中药组及空白对照组 ,分别饲以添加定量中药的饲料与普通饲料 ,于造模前、后及用药 4周、8周各点检测ET值并处死一定数量兔行病理、光镜检查及透射电镜观察。结果示中药组及对照组用药 4周后ET值有差别 (P <0 .0 5 ) ;用药 8周后差别显著 (P <0 .0 1) ;中药组ET值低于对照组。光镜检查示用药 4周后对照组镜下病变加重 ,至 8周时病变严重 ;用药 4周后中药组镜下病变无明显加重 ,至 8周时病变较对照组明显减轻。电镜所示与光镜结果基本相同。证明补肾活血方药能有效改善脊髓血液循环 ,减轻脊髓病变 ;ET水平高低可反映脊髓型颈椎病病变程度及治疗效果 ;把ET作为脊髓型颈椎病诊断及治疗评价的一项客观指标 。
The second Affiliated Hospital of Guangzhou University of TCM,510120 In order to observe the relationship between endothelin(ET) and the curative effect of Kidney-tonifying and Blood-activation formulae for cervical spondylotic myelopathy(CSM),CSM's models of 44 New Zealand white rabbits were setablished by driving screws into C 4～5 to compress the spinal cord. After operation the rabbits were allocated into two groups at random:the Chinese drug group(fed with forage mixed wity herbs)and the control group(fed wity normal forage).Detection of ET and observation of ultrastructral psthological studies were performed at the time of before and after model-making,4w and 8w of treating course. Resulte:The ET level in the Chinese drug group showed significant difference after 4w and 8w of treating course compared wity that in the control group. The histopathological studies showed that after 4w and 8w of treating coures, the pathological change in the Chinese drug group had been ameliorated further, but that in the control group had aggravated severely.The ultramicroscopy studies showed the same tendencies as the histopathological ones.The results demonstrated that herbs had action to improve blood circulation of spinal cord and relieve the pathological change of spimal cord;the level of ET can reflect the pathological change of spimal cord and the curative effect of Chinese drugs.
出处
《中医正骨》
2000年第12期3-6,共4页
The Journal of Traditional Chinese Orthopedics and Traumatology
基金
国家中医药管理局课题 !编号 :91L0 2 6
关键词
脊髓型颈椎病
中医药疗法
肾骨安
血清内皮素
cervical spondylotic myelopathy therapy of TCM endothelin experimental study animal model (Original article on page 3)
