摘要
目的探讨抑郁症患者认知功能损害的特点及发病机制。方法使用汉密尔顿抑郁量表（HAMD）、WCST测验、N—BACK任务、P300及fMRI对24例抑郁患者及匹配对照组进行评定，得出相关指标及影像学结果进行统计分析。结果（1）抑郁组WCST成绩、N—back反应时、P300波幅[（4．12±1．51）μV]、潜伏期[（392．02±23．60）ms]与对照组[P300波幅：（6．42±1．73）μV；P300潜伏期（309．43±21．39）ms]相比差异有显著性（t=4．922，P〈0．01；t=12．726，P〈0．01）。（2）病程和持续性错误数（r=0．596，P〈0．01）、mRT（r=0．518，P〈0．01）呈正相关；P300波幅和完成分类数呈负相关，P300潜伏期和N—back反应时、持续性错误数呈正相关。（3）抑郁组激活相对减弱脑区：双侧额上回、左侧额中回及额下回和顶上小叶。结论抑郁患者表现为以额叶执行功能为主的认知功能损害，病程越长，损害越重。P。潜伏期是反应额叶执行功能的敏感指标。
Objective To investigate the characteristics and relative pathogenesis of cognitive impairment in people with depression. Methods 24 people with depression and 24 healthy controls were evaluated respec- tively with HAMD scale, the WCST test, N-BACK task P30o and fMRI. Results （ 1 ） The WCST scores, N-back reaction （MRT）, the P30o incubation period in depression group were significantly different from those in control group（ P300 wave amplitude（ 4.12±1.51 ）μV vs （ 6.42± 1.73）μV; P300 latency（392.02±23.60） ms vs （ 309.43± 21.39）ms, t=4.922, P〈0.01 ; t= 12.726, P〈0.01）. （2） The illness course had positive correlation with Rep（ r= 0.596, P〈0.01） and mRT（ r=0.518, P〈0.01）.The P300 latency had positive correcation with Rpe（ r=0.929, P〈 0.01 ） and toRT（ r= 0.939, P〈0.01 ）. （3）Compared with control group, the decreased activation area in patients with depression were as follows：bilateral frontal gyrus, left middle frontal gyrus,inferior frontal gyrus and superior parietal lobule. Conclusion The depressive patients exist cognitive impairment mainly in frontal lobe. The longer with the illness, the wose with the impairment.P300 incubation period is a sensitive indicator of the frontal executive function.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2013年第11期985-988,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
基金项目：国家自然科学基金（81271655/1810）
广东省自然科学基金（$2011040004584）
关键词
抑郁症
认知功能
事件相关电位
功能磁共振
Depression
Cognitive function
Event related potential
Fuctional magnetic resonance image
