摘要
抗菌药物包括抗生素(微生物天然产物如青霉素)及人工合成抗菌药(磺胺类、喹诺酮类、呋喃类等)。抗菌约物挽救丫很多细菌感染患者的生命,但在我国也存在抗菌药的过度使用、细菌耐药性高等问题。近十年,我国卫生行政部门及医疗与药学等专业人员在规范抗菌药的临床使用方面做了不少工作,起了一定的作用,但与国际先进经验相比,离抗菌药合理应用还有一定距离。本文回顾近十年我国在抗菌药的临床应用方面所做的工作,分析与国际先进经验的差距。
Overuse of antibacterial agents results in high bacterial resistance rates in China.It was reported that antibacterial agents were used in 69%of inpatients and 21.8%of outpatients in China in 2009.Extented-spectrumβ-1actamase(ESBL)producing strains accounted for 55%in Escherichia coli and 34%in Klebsiella pneumoniae in 2012.Many measures have been taking in recent years by healthcare administrators and professionals in order to make rational use of antibacterial agents,including the establishment of Guiding Principle of Clinical Use of Antibacterial Agents and Regulations for Clinical Application of Antibacterial Agents,and implementation of three years'nationwide inspection on the rational use of antibacterial agents in hospitals.A lot of progresses have been made for clinical use of antibacterial agents in recent years,such as the decreased use of antibacterial agents including prophylactic use in surgel7.Much work needs to be carried out to further improve the rational use of antibacterial agents in the future.Antibacterial agents should be managed professionally and persistently with less administration intervention as done in many countries around the world.
作者
王明贵
Wang Minggui(Institute of Antibioties,Key Laboratory of Clinical Pharmacology of Antibiotics of Ministry of Health,Huashan Hospital,Fudan University,Shanghai,200040,China)
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2013年第23期2495-2497,共3页
Journal of Third Military Medical University
关键词
抗菌药物
合理应用
抗菌药管理
antibacterial agents
rational use
antibiotic stewardship
