摘要
目的：探讨脑出血患者的细胞免疫功能及其临床意义。方法：对４６例脑出血患者及４２例正常对照外周血Ｔ淋巴细胞亚群及血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平进行检测，并对其中 ２１例脑出血患者恢复期外周血Ｔ淋巴细胞亚群及血清ｓＩＬ－２Ｒ水平进行了复查。结果：脑出血组急性期外周血 ＣＤ３数量明显低于对照组，ＣＤ４与对照组比较无显著性差异，ＣＤ８明显高于对照组，ＣＤ４／ＣＤ８比值则显著低于对照组，血清ｓＩＬ－２Ｒ水平显著高于对照组；病情重者、预后差者周围血ＣＤ３数量明显少于病情轻者、预后好者，ＣＤ８数量明显多于病情轻者、预后好者，ＣＤ４／ＣＤ８比值显著低于病情轻者、预后好者，血清ｓＩＬ－２Ｒ水平显著高于病情轻者、预后好者；脑出血组恢复期与急性期比较，周围血ＣＤ３数量明显增多，ＣＤ８明显减少，ＣＤ４／ＣＤ８比值明显升高，血清ｓＩＬ－２Ｒ水平显著降低。结论：脑出血患者细胞免疫功能明显低下。检测外周血Ｔ淋巴细胞亚群分布及血清ｓＩＬ－２Ｒ水平对判断脑出血病情、预后有一定的临床意义。
Objective: To explore the cellular immune and its clinical significance in patients with intracerebral hemorrhage(ICH). Methods: The peripheral blood T lymphocyte subpopulations and serum soluble interleukin 2 receptor (sIL-2R) levels of 46 ICH patients and 42 normal controls (NC) were measured, among them these indices were remeasured in 21 cases during recovery phase. Results: A significant decrease of CD3 cells, not significant change in CD4 cells, a significant increase in CD8 cells, a remarkable decrease of CD4/CD8 ratio and a significant increase in the levels of serum sIL-2R were found in ICH group during acute phase. The variation of peripheral blood T lymphocyte subpopulations and serum sIL-2R levels were related to the disease severity and prognosis of ICH. Compared with those in acute phase of ICH, there were a significant increase in CD8 cells, a remarkable increase CD4/CD8 ratio and a significant decrease in the levels of serum sIL-2R in recovery phase of ICH patients. Conclusion:There was a significant decrease in cellular immune of ICH patients. Measurement of the peripheral blood T lymphocyte subpopulations and serum sIL-2R levels are useful in determining the disease severity and prognosis of ICH.
出处
《卒中与神经疾病》
2000年第4期209-211,共3页
Stroke and Nervous Diseases
关键词
脑出血
T淋巴细胞亚群
SIL-2R
T lymphocyte subpopulations Soluble interleukin 2 receptor Intracerebral hemorrhage
