摘要
目的 :探讨高血压病 (EH)患者血清甲状腺激素的水平及药物干预后的影响。方法 :用放射免疫法测定了 6 6例EH患者和 36例正常血压对照者及 41例EH患者服药 (2 5例服吲达帕胺 2 .5mg/d或 16例服卡托普利 18.75～ 75mg/d) 8周后血清T3 、T4 的变化。结果 :EH患者血清T3 、T4 水平显著高于对照组 ,均P <0 0 1;服吲达帕胺组或卡托普利组 8周后血压 ,T3 和T4 水平较服药前均显著降低 (P <0 0 5 )。结论 :EH患者血清T3 、T4 水平增高 ;吲达帕胺 ,卡托普利有效降血的同时均能显著降低血清T3 、T4 水平 ,甲状腺激素的失控可能参与高血压的形成或维持。
Objective: To investigate the level of thyriod hormone and its changes with antihypertensive drug in essential hypertensive patients. Methods: The triiodothyronine (T 3) and thyroxine(T 4) were measured by radioimmunoassay in 66 hypertensive patients,36 normotensive controls. 41 hypertensive patients with indapamide( n =25, 2.5 mg qd) or captopril ( n =16, 6.25～25 mg tid) for 8 weeks. Results:The serum of T 3 and T 4 in hypertensive patients were higher.There are significantly differences compared with patients and controls (all P <0 01).After 8 weeks treatment, the T 3 and T 4 were decreased in both groups (all P <0 05) along with blood pressure lowering. Conclusion:The results suggested that serum contents of T 3 and T 4 were higher in essential hypertention.Both indapamide and captopril may reduce the serum level of T 3 and T 4 when the blood pressure was effectively controlled.
出处
《高血压杂志》
CAS
CSCD
2000年第4期330-331,共2页
Chinese Journal of Hypertension
