摘要
目的 :观察重组葡激酶 (recombinantstaphylokinase ,r-Sak)治疗实验性视网膜中央动脉阻塞的效果及其对全身的影响。方法 :光化学法建立视网膜中央动脉阻塞模型 ,静注r -Sak、重组链激酶和尿激酶溶栓 ,观察血管再通情况及其对循环系统的影响。结果 :r-Sak的治疗效果明显 ,对全身的影响较小。结论 :r -Sak是一种高效、安全、特异性强的溶栓药 。
Objective:To inspect the results of recombinant staphylokinase in the treatment of experimental central retinal artery occlusion,and also to observe the changes of fibrinolytic activity in the systemic circulation.Methods:The animal model was set up by photochemical method and then the thrombus was to be dissolved by intravenous injetion of recombinant staphyloinase(r-Sak),recombinant streptokinase (r-SK) and urokinase (UK).The patency of the artery was evaluated by FFA.Moreover,the changes of fibrinolitic activity in the blood were exmined by phlebotomizing.Results:The market therpeutic effect had been obtained and no significant systemic fibrinolytic activation was observed in r-Sak group.Conclusions:R-Sak is capable of lysing thrombus in retinal artery without significant activation of circulating plasminogen,it may have potential bright future in treatment of occlusion of central retinal artery clinically.
出处
《中国现代医学杂志》
CAS
CSCD
2000年第12期22-24,共3页
China Journal of Modern Medicine
关键词
重组葡激酶
重组链激酶
尿激酶
视网膜动脉阻塞
光化学法
Recombinant Staphylokinase
Recombinant Streptokinase
Uroinase
Retinal Artery Occlusion
Photochemical Method
