摘要
用一步法微囊技术包裹新生猪胰岛 ,并控制微囊内胰岛数量 ,分别移植于链脲霉素 (STZ)制备的糖尿病模型大鼠 ,每组 10只 ,对照组微囊内 3～ 4个胰岛 ,实验组微囊内含一个胰岛。植入胰岛数量均为2 0 0 0个 /鼠 ,移植后的第 10天各组大鼠均停用胰岛素。结果表明 :实验组大鼠血糖值为 (6 .6 4± 1.10 )mmol/L。半数以上血糖在正常范围并存活达 147d以上。对照组为 (9.83± 1.33)mmol/L。血糖维持该水平70余天后逐渐上升 ,其中 3只血糖高水平情况下存活 98d。两组相比有非常显著差异 (P <0 .0 1)。结果表明 :减少微囊内胰岛数量 ,可提供足量营养 ,是提高疗效的有利措施。
Islets of newly born pig were microencapsulated with one-step method. Part I: every microcapsule cantains only one pancreat islet; Part II: three of four. The diabetes mellitus rats were induced by strptozotocin and divided into experimental group and control group with part II. Every rat received 2000 islets. After transplantation, blood glucose level of experimental group rats decreased to 6.64±1.10mmol/L; control group rats were 9.38±1.33mmol/L. There is obvious difference between two groups. The result showed the capsule containing one islet have better effect for treat diabetes millitus.
出处
《中国现代医学杂志》
CAS
CSCD
2000年第11期7-8,共2页
China Journal of Modern Medicine
基金
山东省自然科学基金!重点资助项目 (Z96C0 10 0 2 )
关键词
胰岛
糖尿病
微囊
移植
新生猪
大鼠
Pancreat Islets
Diabetes Millitus
Microcapsule
Graft
Newly Born Pigs
Rats$$$$
