摘要
探讨创伤性休克发生后血浆内毒素、TNFα、IL - 6、NO的变化及其意义。方法 :选用大白兔 2 4只 ,分为创伤性休克组 (12只 ) ,对照组 (12只 ) ,休克组观察休克前后血浆内毒素、TNFα、IL - 6、NO的动态变化 ,对照组观察手术前后上述指标的变化 ,并观察动物 2 4h、48h存活率。结果 :大白兔发生创伤性休克后血浆内毒素、TNFα、IL - 6、NO的水平与休克前及对照组比较有明显升高 ,死亡动物中血浆上述物质水平显著高于存活动物。结论 :内毒素血症、细胞因子、NO在创伤性休克向不可逆发展过程中发挥着重要作用。
Objective: To study the changes and significance of endotoxin, cytokines and nitric oxide after traumatic shock. Methods: 24 rabbits were randomly divided into traumatic shock group (12 rabbits), control group (12 rabbits). After establishing traumatic shock model of rabbits, plasma levels of endotoxin, TNFα, IL-6 and NO were detected at preshock and postshock. The survival rates of 24h and 48h were observed. Results: The plasma levels of endotoxin TNFα, IL-6 and NO were markedly higher after shock than those of before shock and control group, and maintained at high level. The plasma levels of endotoxin, cytokines and NO in nonsurvivors were higher than those of surviving animals. Conclusions: The endotoxin, cytokines and NO play an important role in the development of traumatic shock.
出处
《中国现代医学杂志》
CAS
CSCD
2000年第11期1-3,共3页
China Journal of Modern Medicine
