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NADPH氧化酶家族与高血压血管重构 被引量：6

NADPH oxidase family and vascular remodeling in hypertension
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摘要 高血压及其并发症的发生、发展与血管重构密切相关。高血压过程中血管重构的类型、特点以及发生机制已成为高血压研究领域的热点之一。高血压血管重构的机制尚未完全明了,研究表明活性氧诱导的氧化应激参与了高血压血管重构的各个环节。NADPH氧化酶是体内生成活性氧的主要酶类,大量研究证实NADPH氧化酶来源的ROS在高血压血管重构的发生、发展中起重要作用。本文就NADPH氧化酶介导高血压血管重构的作用及机制作一综述。 The development and complications of essential hypertension （EH） are closely related to vascular remodeling. The types, characteristics and mechanisms of vascular remodeling in the process of hypertension development have attract extensive attention. The mechanism of vascular remodeling in EH is not fully understood. Recent studies suggest that reative oxygen species plays an important role in the development of vascular remodeling. NADPH oxidase is a major enzyme in generation of reactive oxygen species in vivo. Previous studies have shown that the NADPH oxidase-derived oxygen species plays an important role in the occurrence and development of vascular remodeling remodeling in hypertension. In this paper, we review the role and mechanism of NADPH oxidase in vascular in hypertension.
作者 葛良清 石瑞正 张国刚
机构地区 常德市第四人民医院心血管内科 中南大学湘雅医院心内科
出处 《国际病理科学与临床杂志》 CAS 2013年第5期442-448,共7页 Journal of International Pathology and Clinical Medicine
关键词 NADPH氧化酶 高血压 血管重构 NADPH oxidase hypertension vascular remodeling
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献76

  • 1Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis[J]. Hypertension, 2001, 38(3 Pt 2): 581-587.
  • 2Gibbons GH, Dzau V]. The emerging concept of vascular remodeling[J]. N EnglJ Med,1994, 330(20): 1431-1438.
  • 3Dzau VJ, Gibbons GH, Morishita R, et al. New perspectives in hypertention research: potentials of vascular biology[J]. Hypertension, 1994,23(6Pt2): 1l32-114O.
  • 4Fortuno A, San Jose G, Moreno MU, et al. Oxidative stress and vascular remodeling[J]. Exp Physiol,2005,90(4): 457-462.
  • 5Touyz RM. Reactive oxygen species in vascular biology: role in arterial hypertension[J]. Expert Rev Cardiovasc Ther, 2003, 1 ( 1): 91-106.
  • 6Paravicini TM, Touyz RM. Redox signaling in hypertension[J]. Cardiovasc Res, 2006, 71(2): 247-258.
  • 7Droge W. Free radicals in the physiological control of cell function[J]. Physiol Rev, 2002, 82(1): 47-55.
  • 8Cakir Y, Ballinger SW. Reactive species-mediated regulation of cell signaling and the cell cycle: the role of MAPK[J]. Antioxid Redox Signal, 2005, 7(5/6): 726-740.
  • 9Lyle AN, Griendling KK. Modulation of vascular smooth muscle Signaling by reactive oxygen species[J]. Physiology (Bethesda), 2006, 21: 269-280.
  • 10Winterbourn CC, Hampton MB. Thiol chemistry and specificity in redox signaling[Jl. Free Radic Bioi Med, 2008, 45( 5): 549-561.

同被引文献55

  • 1赵凯,杨万松.氧化应激与高血压血管内皮损伤[J].天津医药,2006,34(12):907-909. 被引量：11
  • 2BAUMBACH G L, HEISTAD D D. Remodeling of cerebral arterioles in chronic hypertension[J]. Hypertension, 1989, 13 (6Pt2) : 968-972.
  • 3Liu S, Li Y, Zhang Z. od-Adrenergic receptors mediate combined signals initiated by mechanical stretch stress and norepinephrine leading to accelerated mouse vein graft ath- erosclerosis[ J]. J Vasc Surg, 2013, 57 (6) : 1 645-656.
  • 4Li Y, Liu S, Zhang Z. RAGE mediates accelerated diabet- ic vein graft atherosclerosis induced by combined mechani- cal stress and AGEs via synergistic ERK activation [ J ]. PloS One, 2012, 7(4) : e35016.
  • 5Staiculescu MC, Foote C, Meininger GA, et al. The role of reactive oxygen species in microvascular remodeling [ J ]. Int J Mol Sei, 2014, 15 (12) : 23 792-835.
  • 6Mulens-Arias V, Rojas JM, Prez-Yagiie S. Polyethyleni- mine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podo- some dynamics[ J]. Biomaterials, 2015, 52: 494-506.
  • 7Shirai T, Hilhorst M, Harrison DG. Macrophages in vas- cular inflammation-from atherosclerosis to vasculitis [ J ]. Autoimmunity, 2015, 48 (3) : 139-151.
  • 8Li C, Xu Q. Mechanical stress-initiated signal transduc- tion in vascular smooth muscle cells in vitro and in vivo [J]. Cell Signal, 2007, 19 (5) : 881-891.
  • 9Zhang Z, Zhang M, Li Y. Simvastatin inhibits the addi- tive activation of ERK1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stretch stress and oxLDL through LOX-1 pathway [ J ]. Cell Signal, 2013, 25 (1) : 332-340.
  • 10魏万林,刘文,张薇,田国祥.氧化应激与血管重构[J].实用老年医学,2008,22(1):66-69. 被引量：4

引证文献6

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国际病理科学与临床杂志
2013年 第5期

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