摘要
目的探讨应用高频超声评价糖化血红蛋白(HbA1c)对2型糖尿病(T2DM)患者颈动脉内-中膜厚度(IMT)及颈动脉粥样硬化血管重构的影响。方法将100例T2DM患者根据HbA1c水平分为两组:HbA1c<9%为A组(51例),HbA1c≥9%为B组(49例)。C组为50名正常人。应用高频超声测量颈动脉IMT、斑块部位的血管总面积(TVA)及管腔面积(LA),计算重构指数(RI)及斑块总积分。实验室检测HbA1c;分析其与颈动脉IMT的关系。结果 A组和B组颈总动脉干、颈总动脉分叉处、颈内动脉IMT、颈动脉平均IMT及斑块总积分均高于C组(P均<0.05);B组颈总动脉干、颈总动脉分叉处、颈内动脉IMT、颈动脉平均IMT及斑块总积分高于A组(P均<0.05)。A组及B组HbA1c与颈动脉平均IMT呈正相关(P<0.05)。A组、B组的重构发生率均高于C组(P均<0.01);A组与B组的重构发生率差异无统计学意义(P>0.05)。B组的负性重构发生率高于A组及C组(P均<0.05);A组与C组间重构类型的差异无统计学意义(P>0.05)。A组与C组正性重构发生率高于负性重构发生率(P均<0.05);B组负性重构率高于正性重构发生率(P<0.05)。结论 T2DM患者的HbA1c水平与颈动脉IMT密切相关,HbA1c可能影响颈动脉血管重构;应用高频超声可较为准确地评价T2DM患者HbA1c与颈动脉IMT及血管重构的关系。
Objective To observe the impact of glycosylated hemoglobin （HbA1c） on intima-medial thickness （IMT） of carotid and remodeling of carotid atherosclerosis in type 2 diabetes mellitus （T2DM） patients with high-frequency ultrasound. Methods A total of 100 patients with T2DM were divided into two groups according to the level of HbA1c,including 51 with HbA1c level 9% in group A and 49 with HbA1c level ≥9% in group B. Meanwhile,50 healthy subjects were enrolled in group C as normal controls. All T2DM patients and healthy subjects were examined with high-frequency ultrasound. The IMT of carotid,total vessel area （TVA） and lumen area （LA） of the vessels in which atherosclerotic plaque could be found were measured,while the remodeling index （RI） and the total plaque score were calculated. Moreover,the detection of HbA1c was performed,and the relationship between HbA1c and carotid IMT was analyzed. Results The IMT of the trunk,bifurcation site of common carotid artery,the internal carotid artery,the average IMT and the total plaque score in group A and B were higher than those in group C （all P0.05）. The IMT and the total plaque score in group B was higher than those in group B （all P0.05）. Positive correlation was observed between HbA1c and the average IMT in group A and B （P0.05）. The remodeling rate of carotid atherosclerosis in group A and B was higher than that in group C （P0.05）. There was no statistical difference of remodeling rate between group A and B. The negative remodeling rate of group B was higher than those of group A and C （P0.05）,while no statistical difference was found in group A and C. The rate of negative remodeling in group B was higher than that of positive remodeling in group A and C （all P0.05）,while the rate of negative remodeling was higher than that of positive remodeling in group B （P0.05）. Conclusion In T2DM patients,HbA1c is closely correlated with carotid IMT,and the remodeling of carotid atherosclerosis is influenced by HbA1c. High-frequency ultrasound is a convenient and precise method in assessing the the impact of HbA1c on IMT of carotid and remodeling of carotid atherosclerosis in T2DM patients.
出处
《中国医学影像技术》
CSCD
北大核心
2010年第12期2289-2292,共4页
Chinese Journal of Medical Imaging Technology
基金
国家科技支撑计划项目(2006BAI02B08)
关键词
糖尿病
颈动脉
内-中膜厚度
糖化血红蛋白
超声检查
Diabetes mellitus
Carotid arteries
Intima-medial thickness
Glycosylated hemoglobin
Ultrasonography
