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间充质干细胞的免疫调节特性及其在实体器官移植中的应用 被引量：1

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摘要 自1954年人类首例肾移植成功实施以来,器官移植已取得了长足的进步[1].对于许多危重病例及终末期疾病患者来说,器官移植是唯一有效的治疗手段.为了保证器官移植的临床效果,术后患者必须长期使用免疫抑制剂.但这些药物的免疫抑制作用是非特异性的,影响受体全身免疫细胞的功能,产生许多不良反应,包括增加患者感染及患恶性肿瘤的风险,引起心血管疾病,导致代谢紊乱和对移植物直接产生毒副作用等,最终导致移植物失去功能[2].因此,如果诱导产生供体特异性免疫耐受就能克服上述缺点,使移植物维持良好功能并长期存活.
作者 张小然 彭延文 项鹏
机构地区 中山大学干细胞与组织工程研究中心 中山大学附属第三医院细胞与基因治疗转化医学中心
出处 《器官移植》 CAS CSCD 2013年第6期314-319,369,共7页 Organ Transplantation
基金 国家自然科学基金面上项目(81270646)
关键词 间充质干细胞 器官移植 免疫调节 免疫耐受 淋巴细胞
分类号 R617 [医药卫生—外科学]
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参考文献53

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同被引文献11

  • 1李浩,侯辉.《内经》“鼽”字辨析[J].中国中西医结合耳鼻咽喉科杂志,2007,15(1):71-72. 被引量：7
  • 2Mc Donald JL,Cripps AW,Smith PK,et al.The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis:a narrative review and proposed model.Evid Based Complement Alternat Med,2013,2013:591796.
  • 3Chen M,Xu S,Zhou P,et al.Desloratadine citrate disodium injection,a potent histamine H1 receptor antagonist,inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades.Eur J Pharmacol.2015,pii:S0014-2999(15):30292-30292.
  • 4Mcdonald JL,Cripps AW,Smith PK.mediators,receptors,and signalling pathways in the anti-inflammatory and antihyperalgesic effects of acupuncture.Evid Based Complement Alternat Med,2015,2015:975632.
  • 5Jiang YL,Yin XH,Shen YF,et al.Low frequency electroacupuncture alleviated spinal nerve ligation induced mechanical allodynia by inhibiting TRPV1 upregulation in ipsilateral undamaged dorsal root ganglia in rats.Evid Based Complement Alternat Med,2013,2013:170910.
  • 6Solèr M,Matz J,Townley R,et al.The anti-Ig E antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics.Eur Respir J,2001,18(2):254-261.
  • 7Casale R,Racine A,Sallas W,et al.Relationship between the clinical efficacy of rhu MAb-E25(E25)and serum free Ig E in seasonal allergic thinitis.J Allergy Clin Immunol,2000,105:S357.
  • 8Adelroth E,Rak S,Haahtela T,et al.Recombinant humanized m Ab-E25,an anti-Ig E m Ab,in birch pollen-induced seasonal allergic rhinitis.J Allergy Clin Immunol,2000,106(2):253-259.
  • 9李鸿霞.电针配合神阙灸治疗过敏性鼻炎37例[J].湖北中医杂志,2010,32(2):68-68. 被引量：11
  • 10王娥.电针配合穴位注射及拔罐疗法治疗过敏性鼻炎100例[J].内蒙古中医药,2012,31(19):53-53. 被引量：2

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器官移植
2013年 第6期

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