摘要
目的 探讨免疫球蛋白在 MS病理过程中的作用机制与变化规律。方法 本文应用免疫组化法对 7例 MS患者的脑组织进行了 Ig A、Ig G、Ig M及 GFAP染色观察。结果 远隔病灶的白质区可见胞浆 Ig A、Ig G、Ig M及 GFAP阳性表达的星形胶质细胞 ;急性炎症坏死病灶内吞噬细胞胞浆 Ig A、Ig G、Ig M呈较强阳性表达 ;并且神经细胞 (主要为锥体细胞 ) Ig A、Ig G、Ig M也有较强的阳性表达。结论 MS是一种涉及中枢神经系统多种细胞的复杂免疫性疾病 ,可能与病毒感染有关。
Objective To research the role and changing rules of immunoglobulin in the pathologic process of MS. Methods We studied the brain tissues of seven autopied MS patients by immunohistochemical method. Results Staing of IgA,IgG and IgM was positive in the cytoplasm of both astrocytes in the peripherial areas of the white matter and phagocytes in the acute inflammatory necrosis areas. The staining of GFAP was positive in the cytoplasm of astrocytes in the peripheral areas. The cytoplasm staining of IgA,IgG and IgM was also foung positive in the neurons of CNS,especially in the pyramidal cells. Conclusion MS is a complex immunological disease in which many kinds of cells of the CNS take part in and may be related to the infection of virus of the CNS.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2000年第6期343-344,共2页
Journal of Apoplexy and Nervous Diseases
