摘要
目的探讨免疫固定电泳在慢性淋巴细胞白血病(CLL)中的临床应用价值。方法对41例检出M蛋白的CLL患者的血清样本进行免疫固定电泳,结合血清总蛋白、球蛋白、免疫球蛋白定量等实验室检查,分析CLL患者的M蛋白特征,研究免疫固定电泳对CLL的诊断意义。结果 41例患者样本经免疫固定电泳分型,发现以IgG型为主,IgG型、IgM型、IgA型分别占53.6%、36.6%、9.8%,其免疫球蛋白定量结果显示IgG型和IgM型对应的免疫球蛋白显著高于健康对照组,但很少引起总球蛋白增加。IgG型CLL患者的IgG水平显著低于IgG型MM患者。结论免疫固定电泳结合免疫球蛋白定量分析有助于CLL的鉴别诊断。
Objective To investigate the clinical value of immune electrophoresis in chronic lymphocytic leukemia （CLL）. Methods M protein was detected in 41 serum samples of CLI. patients. Immunofixation electrophoresis,tests of serum total pro lein,globulin,immunoglobulin quantification,and analysis of the M protein were performed in the serum samples. Results After immunofixation electrophoresis, the serum samples contained mainly the IgO type. Types of IgG, IgM, and IgA accounted for 53.6 %, 36.6 %, and 9.8 %, respectively. The immunoglobulin quantitative results showed that types of IgG and IgM both had sig nificantly higher corresponding immunoglobulin than the healthy control group. However, the total globulin rarely increased. IgG levels of CLL patients（IgG type） was significantly lower than the MM patientsfIgG type）. Conclusion Immune electrophoresis combined with immunoglobulin quantitative analysis help in the differential diagnosis of CLL.
出处
《国际检验医学杂志》
CAS
2013年第22期2978-2979,共2页
International Journal of Laboratory Medicine
基金
江苏省实验诊断学重点实验室资助项目(XK201114)
关键词
慢性淋巴细胞白血病
M蛋白
免疫固定电泳
免疫球蛋白
chronic lymphoblastic leukemia
M protein
immunofixation electrophoresis
immunoglobulin
