摘要
目的:探讨B细胞慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)的免疫表型特点。方法:应用流式细胞仪分析24例初诊B-CLL患者外周血或骨髓的免疫表型。结果:24例初诊CLL患者21例CD5+、CD23+最终被确诊为CLL,其余3例分别被诊断为套细胞淋巴瘤(MCL)和滤泡淋巴瘤(FL)。结论:免疫分型对CLL的诊断及鉴别诊断有重要意义,CD38和ZAP70的表达是CLL患者预后的重要指标。
Objective：To investigate the immunophenotypic characteristics of B-cell chronic lymphocytic leukemia（B-CLL）.Methods： Flow cytometry was used to analyze the phenotype of peripheral blood or bone marrow from 24 cases who were newly diagnosed as B-CLL.Results：Twenty one out of 24 cases of CLL patients was diagnosed of CLL finally because of CD5^＋,CD23^＋,the rest cases were diagnosed as mantle cell lymphoma（MCL） and follicular lymphoma（FL）.Conclusion： Immunophenotyping was very useful for the diagnosis and differential diagnosis of CLL,and the expression of CD38 and ZAP70 were important prognostic indicators of CLL patients.
出处
《现代肿瘤医学》
CAS
2012年第11期2364-2366,共3页
Journal of Modern Oncology
基金
湖北省自然科学基金(编号:2011CDC105)
