摘要
采用超数排卵技术,在相对较低剂量(0.25、0.50、0.75和1.00Gy)X线照射下,观察了全身照射雌性小鼠对次级卵母细胞染色体的损伤。各受照组染色体畸变率均明显高于对照组,并与剂量足线性相关(Y_总=0.0091+0.1230D)。染色体着丝粒分离率同样都高于对照组,在0—0.75Gy范围内,其发生率与剂量呈线性相关(Y=-0.0002+0.0442D)。并进一步估算,在0.75和1.0Gy组预期其子代易位携带者的再现率为0.22％和0.36％。
The chromosome damage caused by relative low doses (0.25, 0.50.0.75 and 1.00 Gy) of X-rays was examined in secondary oocytes of mice. The fre-quency of chromosome aberrations was significantly higher in each X-irradiated groupthan that in control group with the tendency of increasing linearly with X-rays dose(Y=0.0091+0.1230 D), The frequency of centromere splits was also markedly hig-her in each irradiated group than that in control. In the dose range of 0-0.75 Gy.the dose-effect relationship was fitted well to linear equation, eg. Y=-0.0002+0.0442 D. Using the frequency of chromatid aberrations in M Ⅱ, the risk of balancedtranslocations in the offspring were predicted to be 0.22% and 0.36% in the 0.75and 1.00 Gy groups respectively.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1991年第2期79-82,共4页
Journal of Radiation Research and Radiation Processing
关键词
低剂量
卵母细胞
染色体
畸变
Low dose
Mouse oocyte
Chromosome aberration
Carrier of the translocation.
