摘要
本文用^(60)Coγ线0.1—0.5Gy照射人离体血,用胞质分裂阻断微核法(CB法)建立微核的剂量效应曲线并与常规法比较。结果表明,两种方法皆适于拟合直线方程式(y=α+bD),但CB法的截距(自发微核率)和斜率远远大于常规法,CB法不仅比常规法省时,而且更灵敏和可靠。
A dose-effect relationship of micronuclei of human lymphocytes induced in vitro by ^(60)Co gamma rays(0.1—0.5Gy)was established by a CB method and was comparated with that establishedby the conventional method.All data obtained by both CB and conventional methods can well be fittedto the linear regression y=a+bx,but for CB method,the intercept(i.e.the frequency of sponta-neous micronucleus)and the slope was significantly higher than these for the conventional method.Theresults suggest that,in addition of saving time,the CB method is more sensitive and reliable than theconventional method.
出处
《辐射防护》
CAS
CSCD
北大核心
1991年第6期465-469,共5页
Radiation Protection
关键词
CB法
微核率
剂量效应曲线
^(60)Co-γ-rays
Low Dose
Dose-response Curve
Culture of Lymphocytes
Cytokinesis-block Micronueleus Method
