摘要
应用本研究组已经建立的LC-MS方法,采用双周期自身交叉设计研究Beagle犬灌胃、静注给予槐果碱后的药代动力学,结果显示两种给药方式下槐果碱的药时曲线均符合二房室模型,消除半衰期基本一致,分别为(2.75±0.17)h和(2.28±0.10)h;研究还表明,该药吸收快、体内分布快,Beagle犬灌胃的绝对生物利用度为45.28%。
An LC-MS method established and reported by our research group was used to investigate the pharmacokinetics of sophocarpine according to a two-period crossover design in Beagle dogs after intragastric and intravenous administration.The results showed that the drug disposition through both routs conformed to the two-compartment model,the elimination half-life for intragastric and intravenous administration were （2.75±0.17） h and （2.28±0.10） h respectively.The results indicated that sophocarpine was absorbed and distributed quickly in Beagle dogs.The absolute bioavailability of sophocarpine with intragastric administration was 45.28％.
出处
《药学与临床研究》
2013年第5期513-515,共3页
Pharmaceutical and Clinical Research
