摘要
目的 研究巨乳症的临床与病理学特点,为今后巨乳症动物模型的建立和体内研究奠定一定的基础,同时也为腺性乳房肥大症的临床治疗提供相关的实验依据.方法 采用苏木精-伊红染色对180例肥大乳房及45例正常体积乳房组织病理学特征进行观察,免疫组织化学法检测肥大乳房组和正常体积乳房组乳腺组织中雌激素相关受体gamma表达及定位.结果 巨乳症乳腺组织与正常体积乳房相比,肥大乳房乳腺导管明显扩张,导管上皮乳头状增生明显,免疫组化染色见乳腺组织腺泡和导管上皮细胞雌激素相关受体gamma强表达.结论 巨乳症增生乳腺组织内雌激素相关受体gamma表达增高,可能与巨乳症的发生有关.
Objective To study the clinical and pathologic changes in gigantomast.Methods Tissue sections were prepared from 180 cases of breast hypertrophy and 45 cases of normal breast tissues.The morphological changes and the expression and localization of ERRγwere evaluated on the HE and immunohistochemistry stained sections between hypertrophy and normal breast tissues.Results Compared with normal breast,hypertrophic breast showed expended ducts and obvious hyperplasia of the duct epithelial papillary.Hypertrophic breast tissues demonstrated strong expression of ERR-γ in ducts and lobules.Conclusions Upregulated expression of ERRγ is identified in hypertrophic breast tissues that may associate with the development of gigantomastia.
出处
《国际外科学杂志》
2013年第10期665-668,F0003,共5页
International Journal of Surgery
关键词
巨乳症
乳房肥大
受体
雌激素
雌激素相关受体gamma
病理状态
体征和症状
治疗结果
Gigantomastia
Breast hypertrophy
Receptors, estrogen
Estrogen-related receptor gamma
Pathological conditions, signs and symptonis
Treatment outcome
