摘要
本研究应用 Wistar 雄性大鼠,接受10Gy X 射线睾丸局部照射,分别于照射后1、23、63及97天处死,观察下丘脑内源性阿片肽、垂体和睾丸内分泌功能的变化,试图阐明电离辐射神经内分泌效应及其作用机理。实验结果表明,照射后1天,下丘脑β-内啡肽(B-EP)含量明显增加,而血清黄体生成素(LH)、卵泡刺激素(FSH)和睾丸酮(TS)及睾丸环磷酸腺苷(cAMP)含量有不同程度的降低;照射后23天,β-EP 下降,并低于对照组,而 LH、FSH、TS 及 cAMP 明显高于对照组;照射后63天,β-EP 仍维持照射后23天的水平,亮氨酸脑啡肽(L-Enk)明显降低,LH 和 FSH 仍持续增高,而 TS 和 cAMP 明显低于对照组;照射后97天,LH 和 FSH 回降,但仍明显高于对照组,TS 和cAMP 仍持续降低,睾丸组织发生严重损伤。
In present study,the changes of hypothalamic endogenous opiate peptides and the endocrinefunction of pituitary and testes were observed at 1,23,63 and 97 days after exposure of testes to 10Gy X-rays in male Wistar rats to attempt to clarify the neuroendocrine effect of ionizing radiationand its mechanism.One day after irradiation,hypothalamic β-endophin(β-EP)content Increased sig-nificantly,but serum luteinizing hormone(LH),follicle-stimulating hormone(FSH)and testosterone(TS)and cAMP content in tests were lowered in varying degrees.Twenty three days after irradia-tion,hypothalamic β-EP content decreased,while serum LH,FSH,TS and testicular cAMP contentincreased very significantly.Sixty three days after irradiation,the level of hypothalamic β-EP stillwas the same as that at 23 days after irradlation,hypothalamic leu-enkephacin(L-Enk)content de-creased significantly,serum LH and FSH levels still continued to increase up,while serum TS and tes-ticular cAMP contents declined very significantly.Ninety seven days after irradiation,serum LH andFSH levels returned to lower,serum TS and testicular cAMP content still continued to decrease,andin testicular tissue,serious lesion occured.
出处
《辐射防护》
CAS
CSCD
北大核心
1991年第3期187-192,共6页
Radiation Protection
关键词
睾丸
X射线
神经递体
鼠
Testes
X-rays
Neuroendocrine
Rats
