摘要
初生48h内去胸腺的成年雄性大鼠下丘脑-垂-体-性腺及皮质系统功能发生改变。经10GyX线头部照射后2天,除了下丘脑M-Enk含量增加外,血清LH和FSH、血尿睾丸酮和皮质酮、垂体和睾丸cAMP以及下丘脑β-EP和L-Enk含量都有不同程度降低,与正常雄性大鼠头部照射后的变化不一致。这些结果提示,由于去胸腺大鼠影响了神经内分泌功能,不可能产生正常大鼠头部照射后所见到的那些变化。
The present study showed that the funtions of the hypothalamic-pituitary-gonadal and hy-pothalamic-adrenococrtical systems changed in adult male rats thymectomized within 48 h after their birth. Two days later , head irradiation with 10 Gy x-rays was performed in the thymectomized male rats, serum LH and FSH, serum and urine testosterone and corticosterone , pituitary and testicular cAMP and hypothalamic β-EP and L-Enk contents were all reduced in different degrees, except the hypothalamic M-Enk content was increased, indicating that the changes were not in the same direction as those in intact male rats after head irradiation . These results suggest that the changes in head irradiated thymeetomized male rats may differ from the changes seen in head irradiated intact male rats because of the influence of thymectomy on the neuroendocrine functions.
出处
《白求恩医科大学学报》
CSCD
1991年第5期5-7,共3页
Journal of Norman Bethune University of Medical Science
关键词
X线照射
胸腺
神经内分泌
Thymectomized male rats Head irradiation Neuroendocrine
