摘要
为探讨多药耐药基因的表达产物P170 糖蛋白在急性白血病异常表达的临床意义 ,用免疫细胞化学间接免疫荧光法 (APAAP法 )检测 30例急性白血病 (AL)患者。结果 :P170 糖蛋白在 30例急性白血病患者中有 9例表达 ,其中15例难治复发性白血病患者有 10例表达 ,其阳性表达率明显增高 ,化疗缓解率较阴性者明显减低 (P <0 0 5 )。表明P170 糖蛋白异常表达与肿瘤生物学行为关系密切 ,已成为提示急性白血病患者预后的有用指标之一。
To investigate the relationship between the expression of the multidrug resistance associated protein(P\+\{170\}) gene and clinical drug resistance in acute leukemia and the blast crisis of chronic myelogenous. APAAP was used to examine the expression of MDR gene in 30 bone marrow aspirates(peripheral blood) of AL patients and in 3 patients with blast crisis of chronic myelogenous leukemia and 15 normal volunteers peripheral blood mononuclear cells . Results: the positive percentage of P\+\{170\} in recurrent group were significantly higher than that in normal control group. In the newly diagnosed group the first complete remission rate of P\+\{170\} negative patients was significanly higher than that of P\+\{170\} positive patients. It is concluded that the positive rate of P\+\{170\} high expression leads to drug resistance and it is an unfavorable factor to prognosis.
出处
《皖南医学院学报》
CAS
2000年第3期190-191,共2页
Journal of Wannan Medical College
关键词
急性白血病
P^170糖蛋白
基因过度表达
leukemia
drug resistance, multiple
P\+\{170\} glycoprotein
gene expression
prognosis
