摘要
植物来源的核糖体失活蛋白 (ribosome -inactivatingprotein ,RIP)是一类RNAN -糖苷酶 ,它能够对核糖体大亚基上的rRNA进行脱腺嘌呤作用 ,从而破坏核糖体的结构 ,抑制蛋白质的生物合成。核糖体失活蛋白按照一级结构可以分为两类 :Ⅰ型RIP由一条多肽链组成 ,称单链蛋白 ;Ⅱ型RIP是通过二硫键连接的双链蛋白。近年 ,人们发现核糖体失活蛋白具有多核苷酸 :腺苷糖苷酶活性 ,进一步解释了它作为防御蛋白的生物学功能。随着增强因子和其它相关蛋白质的发现 ,人们对核糖体失活蛋白和核糖体的相互作用有了更进一步的了解。
The plant ribosome-inactivating proteins (RIPs) are RNA N-glycosidase that depurinate the largest ribosomal RNA, thus damaging ribosomes, and arresting protein synthesis. They can be divided into two groups according to their primary structure: single-peptide chain proteins, type I RIP; and tow-peptide chain proteins, type II RIP. Recently, it has been found that RIPs are a kind of polynuclentide: adenosine glycosidases, which further accounts for their biological functions as defense proteins. With the cofactors for RIPs and other related proteins being found, the interaction between RIPs and ribosomes is further understood.
出处
《世界科技研究与发展》
CSCD
2000年第5期68-72,共5页
World Sci-Tech R&D
关键词
糖苷酶
核糖体失活蛋白
植物
结构
性质
glycosidase, ribosome-inactivating protein, ribosome, RNA
