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应用图像配准技术推衍肺部四维计算机断层摄影技术剂量分布的可行性分析 被引量:1

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摘要 目的分析应用图像配准技术推衍肺部四维计算机断层摄影技术(4DCT)剂量分布的可行性。方法从10例肺癌患者的4DCT图像中提取出呼气末和吸气末两个相位的图像,首先在呼气末图像上设计调强放疗(IMRT)计划,得到剂量DOUT,然后将此计划移植到吸气末,重新计算剂量,得到移植剂量DIN,接着,2个相位的图像进行三维B样条弹性配准,通过形变矢量场将DOUT映射到吸气末图像,得到推衍剂量DDEF,最后,以DIN为基准剂量,γ(3cm/3%)分析A组(DOUT vs DIN)和B组(DDEE vs DIN)的通过率,并对两组的通过率作配对样本t检验。结果在10例患者中,两组的γ分析通过率差异均有统计学意义(P〈0.05),且B组的平均通过率比A组多0.6%-4.7%,推衍剂量DDEF与DIN之间的差距小于DOUT与DIN之差。结论应用图像配准技术推衍肺部4DCT的剂量分布是可行的。推衍剂量与实际准确剂量之间的差距主要受个体化的呼吸运动幅度和应用不同的形变配准算法的影响。
出处 《广东医学》 CAS CSCD 北大核心 2013年第19期2969-2971,共3页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81170078) 广东省科技计划项目(编号:2011B031800111) 广州市科技计划项目(编号:2011J4300131)
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参考文献19

  • 1PAUMIER A, CRESPEAU A, KRHILI S, et al. Dosimetric studyof the different techniques to deal with respiratory motion for lungstereotactic radiotherapy [ J ]. Cancer Radiother, 2012,16(4):263 -271.
  • 2FRANKS K N, PURDIE T G, DAWSON L A, et al. Incorporatingheterogeneity correction and 4DCT in lung stereotactic body radia-tion therapy ( SBRT) : the effect on target coverage, organ - at-risk doses, and dose conformity[ J]. Med Dosim, 2010,35(2):101 -107.
  • 3MUNCK AF ROSENSCH0LD P,AZNAR M C, NYGAARD D E,et al. A treatment planning study of the potential of geometricaltracking for intensity modulated proton therapy of lung cancer[ J].Acta Oncol, 2010,49(7) : 1141 -1148.
  • 4TIAN Y, WANG Z, GE H, et al. Dosimetric comparison of treat-ment plans based on free breathing,maximum,and average inten-sity projection CTs for lung cancer SBRT [ J ]. Med Phys, 2012 ,39(5) : 2754 -2760.
  • 5ROLAND T, MAVROIDIS P, GUTIERREZ A, et al. A radiobio-logical analysis of the effect of 3D versus 4D image - based plan-ning in lung cancer radiotherapy [ J]. Phys Med Biol,2009,54?18) : 5509 -5523.
  • 6KAVANAGH A, MCQUAID D, EVANS P,et al. Dosimetric con-sequences of inter - fraction breathing - pattern variation on radio-therapy with personalized motion - assessed margins [ J ]. PhysMed Biol, 2011,56(22) : 7033 -7043.
  • 7余辉,张书旭.4DCT图像二维配准与三维配准的区别[J].医疗装备,2011,24(7):6-8. 被引量:8
  • 8张国前,张书旭,余辉,林生趣,谭剑明,韩鹏慧,王琳婧.基于4D-CT最大呼吸气相位图像获取三维肺通气的信息[J].中国组织工程研究,2012,16(52):9807-9812. 被引量:2
  • 9GLIDE HURST C K,HUGO G D, UANG J, et al. A simplifiedmethod of four - dimensional dose accumulation using the mean pa-tient density representation[ J]. Med Phys, 2008, 35(12) : 5269 -5277.
  • 10甄鑫,周凌宏,卢文婷,张书旭,周露.改进Demons算法的验证及其在4D-CT轮廓线推衍中的应用[J].南方医科大学学报,2010,30(12):2619-2624. 被引量:3

二级参考文献46

  • 1习勉,刘孟忠,邓小武,刘慧,黄晓延,张黎,李巧巧,胡永红,蔡玲,崔念基.应用4D-CT技术确定肝癌内靶体积及相关剂量学研究[J].癌症,2007,26(1):1-8. 被引量:12
  • 2张红颖,张加万,孙济洲.改进Demons算法的非刚性医学图像配准[J].光学精密工程,2007,15(1):145-150. 被引量:22
  • 3何瀚,包勇,张黎,黄晓延,黄劭敏,王卫华,刘源,陈利,樊卫,陈明,刘孟忠,崔念基,邓小武.四维CT中MIP融合图像的肺癌内靶体积确定[J].中国肿瘤,2007,16(4):267-271. 被引量:21
  • 4Rietzel E,Chen GTY,Choi NC,et al.Four-dimensional Image-based treatment planning:Target volume segmentation and dose calculation in the presence of respiratory motion[J].Int J Radiat Oncol Bioi Phys.2005,61 (5):1535-1550.
  • 5Rietzel E,Liu AK,Karen P,et al.Design of 4D treatment planning target volumes[J].Int J Radiat Oncol Biol Phys.2006,66 (1):287-295.
  • 6van der Geld YG,van Triest B,Verbakel WF,et al.Evaluation of four-dimensional computed tomography-based intensity-modulated and respiratory-gated radiotherapy techniques for pancreatic carcino ma[J].Int J Radiat Oncol Biol Phys,2008,72(4):1215-1220.
  • 7Cai J,Read PW,Baisden JM,et al.Estimation of error in maximal in tensity projection-based internal target volume of lung tumors:a sim ulation and comparison study using dynamic magnetic resonance imaging[J].Int J Radiat Oncol Biol Phys,2007,69(3):895-902.
  • 8Park K,Huang L,Gagne H,et al.Do maximum intensity projection images truly capture tumor motion?[J].Int J Radiat Oncol Biol Phys,2009,73(2):618-625.
  • 9Ehler ED,Tome WA.Lung 4D-IMRT treatment planning:an evalua tion of three methods applied to four-dimensional data sets[J].Ra diother OncoL 2008,88(3):319-325.
  • 10Admiraal MA,Schuring D,Hurkmans CW.Dose calculations account ing for breathing motion in stereotactic lung radiotherapy based on 4D-CT and the internal target volume[J].Radiother Oncol,2008,86 (1):55-60.

共引文献20

同被引文献10

  • 1张书旭,李文华,徐海荣,林生趣.TLD和仿真盆腔模型核查宫颈癌后装治疗三维剂量分布的研究[J].中国辐射卫生,2005,14(3):167-169. 被引量:2
  • 2Dewitt KD,Hsu IC,Speight J,et al.3D Inverse treatment planningfor the tandem and ovoid applicator in cervical cancer[J].Int J Radiat Oncol Biol Phys,2005,63(4): 1270-1274.
  • 3Jamema SV, Sharma S,Mahantshetty,et al.Comparison of IPSA with dose-point optimization and manual optimization for interstitial template brachytherapy for gynecologic cancers[J].Brachytherapy, 2011,10(4):306-312.
  • 4Adamczyk M,Zwierzchowski G,Malicki J,et al.Evaluation of clinical benefits achievable by using different optimization algorithms during real-time prostate brachytherapy[J].Phys Med,2013,29(1):111-116.
  • 5Trnkov6P,P;tter R,Baltas D,et al.New inverse planning technology for image-guided cervical cancer brachytherapy:descfiption and evaluation within a clinid flame[J].Radiother OncoL2009,93(2):331-340.
  • 6Granero D,P rez-Calatayud J,BaUester F.Monte carlo study of the dose rate distributions for the Ir2.A85-2 and Ir2.A85-1 Ir- 192 afterloading sources[J].Med Phys,2008,35(4):1280-1287.
  • 7Mayank Na,Zdenka Kuncic,Robin Hill,et al.Monte carlo characterisation ofa HDR - (192)Ir cource using Geant4[J].Australasian physical & engineering sciences in medicine,2009,32(1):34.
  • 8P6tter R,Haie-Meder C,Van Lirnbergen E,et al.P-ecoml-nendatiom from Gynaecological (GYN) GEC ESTRO working group(II):concepts and terms in 3D image-based treamlent planning in cervix cancer bmchytherapy-3D dose volume parameters and aspects of 3D miage-based anatomy radiation physics, radiobiology[J].Radiother Oncol,2006,78(1):67-77.
  • 9余辉,张书旭.4DCT图像二维配准与三维配准的区别[J].医疗装备,2011,24(7):6-8. 被引量:8
  • 10刘艺,盛修贵,何铁军,张学良.基于CT定位的三维一体化后装治疗系统的开发和临床应用[J].中国医疗设备,2013,28(5):107-109. 被引量:3

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