摘要
目的分析耐多药肺结核并发呼吸道感染患者的病原菌分布和耐药性,为临床合理用药提供参考依据。方法选取2011年8月-2012年10月住院的134例耐多药肺结核并发呼吸道感染患者为研究对象,采取患者呼吸道分泌物进行病原菌培养及分离,分析病原菌的分布特点,对主要病原菌行药敏试验,分析耐药性。结果共分离病原菌172株,排名前3位病原菌依次为肺炎克雷伯菌、白色假丝酵母菌、大肠埃希菌,分别占28.5%、19.7%、12.8%;肺炎克雷伯菌和大肠埃希菌均对亚胺培南敏感,敏感率分别为100.0%和95.5%,对头孢匹美、头孢他啶较敏感,敏感率>54.0%。结论耐多药肺结核并发呼吸道感染患者呼吸道深部痰培养出的病原菌以革兰阴性菌为主,主要革兰阴性杆菌对亚胺培南及三代以上头孢菌素类抗菌药物具有很高的敏感性。
OBJECTIVE To analyze the distribution and drug resistance of pathogens causing respiratory tract infections in patients with multidrug-resistant tuberculosis so as to guide the reasonable clinical use of antibiotics. METHODS Totally 134 multidrug-resistant pulmonary tuberculosis patients with respiratory tract infections, who were hospitalized from Aug 2011 to Oct 2012, were enrolled in the study, then the respiratory tract secretions were collected for culture of pathogens, the isolated pathogens were identified, the drug susceptibility testing for the main species of pathogens was performed, and the drug resistance was analyzed. RESULTS A total of 172 strains of pathogens were isolated, among which the glebsiella pneumoniae, Candida albicans, and Escherichia coli ranked the top three species, accounting for 28. 5%, 19. 7%, and 12. 8%, respectively. The drug susceptibility rates of the If,. pneurnoniae and E. coli to imipenem were 100.0% and 95.5%, respectively, and the drug susceptibility rates to cefpiramide and ceftazidime were more than 54.0 %. CONCLUSION The gram-negative bacilli cultured from the respiratory deep sputum obtained from the multidrug-resistant tuberculosis patients with respiratory tract infections are the predominant pathogens; the main gram-negative bacilli are highly susceptible to imipenem and more than three generation cephalosporins.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第22期5575-5576,5579,共3页
Chinese Journal of Nosocomiology
基金
重庆市万州区科学技术委员会基金项目(万州科成字2012TY015)
关键词
耐多药肺结核
呼吸道感染
病原菌
分布
耐药性
Multidrug-resistant pulmonary tuberculosis
Respiratory tract infection
Pathogen
Distribution
Drug resistance
