摘要
（Ｚ）或（Ｅ）－１，３－二芳基－２－（１Ｈ－１，２，４－三唑－１－基）－丙烯－１－酮与苯肼在醋酸中反应均生成顺式和反式吡唑啉异构体混合物，但在在三乙胺催化下却只生成反式的异构体。制备了三对顺、反式的１－苯基－３，５－二芳基－４－（１Ｈ－１，２，４－三唑－１－基）－２－吡唑啉衍生物，其结构为＾１Ｈ ＮＭＲ和元素分析证实，初步论证了经α－氮原子的加成－环化反应机理。
The reaction of (Z) &( E) - 1,3 - diaryl - 2 - (1H - 1,2,4 - triazo - 1 - lyl) - 2 - propen - 1 - one and phenylhydrazine in acetic acid medium afforded a mixture of cis and trans 1,3,5- triphenyl - 4 - triazolyl - 2 -pyrazoline. In trietnylamine, only trans isomer was obtained. Three pairs of cis and trans 1,3,5- triphenyl - 4 - triazolyl - 2 - pyrazoline (1a - 1c and 2a - 2c) were obtained altogehter. A reaction machanism via 1,4- addition followed cyclization is postulated.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第6期900-904,共5页
Chinese Journal of Organic Chemistry
基金
国家计划委员会攻关项目(97-563-02-01)
关键词
吡唑啉
α-三唑基查尔酮
苯肼
加成-环化反应
pyrazoline, a - triazolyl chalcone, phenylhydrazine, cyclization mechanism
