摘要
从中药丹皮中提取丹皮酚(2);将2与间硝基苯甲醛在室温下通过Claisen-Schmidt缩合反应合成了新化合物2′-羟基-4′-甲氧基-3-硝基查尔酮(1),其结构经1HNMR,13C NMR和IR表征。研究了1和2对6个细菌和1个酵母菌的抗菌活性,结果表明,两者均有明显地抑菌活性,但1对伤寒沙门菌50127株和福氏志贺菌51065株的抑制和灭活作用更为显著。
Paeonol（2） was extracted and refined from Chinese traditional medicine Paeonia Suffruicosa,and the novel compound 2′-hydroxy-4′-methoxy-3-nitrochalcone（1） was synthesized by Claisen-Schmidt condensation reaction of 2 and m-nitrobenzaldehyde at room temperature.The structure was characterized by 1H NMR,13C NMR,IR and elemental analysis.The antimicrobial activities of 1 and 2 were evaluated by inhibiting the growth of six bacteria and one pathogenic yeast.The results showed that 1 and 2 inhibited the growth of testing bacteria and sterilized them,and 1 showed higher antimicrobial activity especially against Salmonella typhi 50127 and Shigella flexneri 51065.
出处
《合成化学》
CAS
CSCD
北大核心
2010年第4期465-467,共3页
Chinese Journal of Synthetic Chemistry
基金
陕西省教育厅资助项目(04JK137)
陕西理工学院科技创新教改项目(XJG0726)
